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首页> 外文期刊>The European Journal of Neuroscience >The Genetic Absence Epilepsy Rats from Strasbourg model of absence epilepsy exhibits alterations in fear conditioning and latent inhibition consistent with psychiatric comorbidities in humans
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The Genetic Absence Epilepsy Rats from Strasbourg model of absence epilepsy exhibits alterations in fear conditioning and latent inhibition consistent with psychiatric comorbidities in humans

机译：斯特拉斯堡失神癫痫模型的遗传缺失癫痫大鼠表现出与人类精神病合并症相一致的恐惧调节和潜伏抑制改变

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Behavioural, neurological, and genetic similarities exist in epilepsies, their psychiatric comorbidities, and various psychiatric illnesses, suggesting common aetiological factors. Rodent models of epilepsy are used to characterize the comorbid symptoms apparent in epilepsy and their neurobiological mechanisms. The present study was designed to assess Pavlovian fear conditioning and latent inhibition in a polygenetic rat model of absence epilepsy, i.e. Genetic Absence Epilepsy Rats from Strasbourg (GAERS) and the non-epileptic control (NEC) strain. Electrophysiological recordings confirmed the presence of spike-wave discharges in young adult GAERS but not NEC rats. A series of behavioural tests designed to assess anxiety-like behaviour (elevated plus maze, open field, acoustic startle response) and cognition (Pavlovian conditioning and latent inhibition) was subsequently conducted on male and female offspring. Results showed that GAERS exhibited significantly higher anxiety-like behaviour, a characteristic reported previously. In addition, using two protocols that differed in shock intensity, we found that both sexes of GAERS displayed exaggerated cued and contextual Pavlovian fear conditioning and impaired fear extinction. Fear reinstatement to the conditioned stimuli following unsignalled footshocks did not differ between the strains. Male GAERS also showed impaired latent inhibition in a paradigm using Pavlovian fear conditioning, suggesting that they may have altered attention, particularly related to previously irrelevant stimuli in the environment. Neither the female GAERS nor NEC rats showed evidence of latent inhibition in our paradigm. Together, the results suggest that GAERS may be a particularly useful model for assessing therapeutics designed to improve the emotional and cognitive disturbances associated with absence epilepsy.
机译：行为，神经和遗传相似性存在于癫痫，其精神病合并症和各种精神病中，提示常见的病因。啮齿动物的癫痫模型用于表征在癫痫中显而易见的共病症状及其神经生物学机制。本研究旨在评估缺乏癫痫症（即史特拉斯堡（GAERS）和非癫痫控制（NEC）品系的遗传缺失癫痫大鼠）的多基因大鼠模型中的巴甫洛夫恐惧条件和潜在抑制作用。电生理记录证实了在成年GAERS幼犬中存在尖峰波放电，但在NEC大鼠中没有。随后对雄性和雌性后代进行了一系列旨在评估焦虑样行为（高迷宫，旷野，听觉惊吓反应）和认知（巴甫洛夫条件和潜伏抑制）的行为测试。结果显示，GAERS表现出明显更高的焦虑样行为，这是先前报道的特征。此外，使用两种在电击强度上不同的方案，我们发现GAERS的两性都表现出夸张的暗示和语境的巴甫洛夫式恐惧条件，并削弱了恐惧的消亡。在无信号的脚震之后，对恢复条件刺激的恐惧在两个菌株之间没有差异。男性GAERS在使用巴甫洛夫式恐惧条件的范例中也显示出潜在的抑制能力受损，这表明他们可能已经改变了注意力，特别是与先前与环境无关的刺激有关。雌性GAERS和NEC大鼠均未在我们的范例中显示出潜在抑制的证据。总之，结果表明，GAERS可能是用于评估旨在改善与失神癫痫相关的情绪和认知障碍的疗法的特别有用的模型。

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