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首页> 外文期刊>The European Journal of Neuroscience >Variations in cell density in the ganglion cell layer of the retina as a function of ocular pigmentation.
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Variations in cell density in the ganglion cell layer of the retina as a function of ocular pigmentation.

机译：视网膜神经节细胞层中细胞密度的变化随眼睛色素沉着的变化而变化。

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摘要

Ocular melanin regulates retinal development, including cell density gradients in the central retina, a region essential for normal visual acuity. In albinos this region is underdeveloped and peak cell numbers are reduced. It is not known whether there is a dosage relationship between pigmentation and the degree of this underdevelopment, as studies of the retinal effects of albinism have commonly used rodents. These have poorly developed central regions even in the wild type. Rabbits, however, have a unique, highly specialized, visual streak in the central retina where cell density gradients are very steep and these are reduced in albinos. Here, cell densities in the ganglion cell layer of separate groups of rabbits, with different levels of ocular pigmentation and known mutations of the tyrosinase gene coding sequence, were examined. These revealed reductions in peak cell densities and/or in the regions over which high cell densities were maintained in all hypopigmented phenotypes. There was no dosage relationship between levels of pigmentation and deficits in the ganglion cell layer as animals with relatively small reductions in retinal pigment had deficits comparable to those found in albinos. The greatest variability between pigmentation phenotypes was between the two completely unpigmented strains. Consequently, although pigment may regulate the development of the central retina, this study failed to show that it does so in a dose-dependent manner.
机译：眼黑色素调节视网膜的发育，包括视网膜中央区域的细胞密度梯度，而视网膜中央区域是正常视力必不可少的区域。在白化病患者中，该区域发育不足，峰值细胞数量减少。尚不知道色素沉着与这种不发达程度之间是否存在剂量关系，因为研究白化病的视网膜效应已普遍使用啮齿动物。即使在野生型中，这些地区的中部地区发展也不佳。然而，兔子在视网膜中央有一个独特的，高度专业化的视觉条纹，那里的细胞密度梯度非常陡峭，白化病患者的这种密度降低了。在这里，检查了具有不同水平的眼色素沉着和酪氨酸酶基因编码序列的已知突变的兔子的独立组的神经节细胞层中的细胞密度。这些表明在所有色素不足的表型中，峰值细​​胞密度和/或维持高细胞密度的区域降低。色素沉着水平与神经节细胞层缺陷之间没有剂量关系，因为视网膜色素减少相对较小的动物的缺陷与白化病中的缺陷相当。色素沉着表型之间最大的变异是在两个完全无色素的菌株之间。因此，尽管色素可能调节中央视网膜的发育，但这项研究未能证明其以剂量依赖性方式起作用。

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