首页> 外文期刊>The European Journal of Neuroscience >Dissecting the projections of different groups of raphe serotonergic neurons (commentary on Bang et al.).
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Dissecting the projections of different groups of raphe serotonergic neurons (commentary on Bang et al.).

机译:剖析不同组的山楂血清素能神经元的投影(Bang等评论)。

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摘要

The serotonergic system modulates-complex brain functions in anatomically widely distributed target regions. Elucidation of the topographical organization of serotonergic projections and the potentially regionally specific regulation of serotonergic neurotransmission has remained a major challenge for neuroscientists. The anatomical organization of serotonergic systems illustrates the complexity of the problem. Individual neurons are highly collateralized and project to diverse regions (Lowry, 2002). Moreover, they contact other serotonergic neurons and maintain negative-feedback loops (Barnes & Sharp, 1999; Sharp et al., 2007; Jensen et al., 2008); such interactions between separate groups of serotonergic neurons are likely to have major impacts on synaptic mechanisms and behavior.
机译:血清素能系统在解剖学上广泛分布的靶区域中调节复杂的脑功能。阐明血清素能投射的地形组织和血清素能神经传递的潜在区域特定调节仍然是神经科学家面临的主要挑战。血清素能系统的解剖学组织说明了该问题的复杂性。单个神经元高度抵押,并投射到不同的区域(Lowry,2002)。而且,它们接触其他血清素能神经元并维持负反馈回路(Barnes&Sharp,1999; Sharp等,2007; Jensen等,2008);血清素能神经元的不同组之间的这种相互作用可能会对突触机制和行为产生重大影响。

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