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首页> 外文期刊>The European Journal of Neuroscience >Control over a stressor involves the posterior dorsal striatum and the act/outcome circuit
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Control over a stressor involves the posterior dorsal striatum and the act/outcome circuit

机译：控制应激源涉及后背纹状体和行为/结果回路

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摘要

Controllable/escapable tailshocks (ESs) do not produce the behavioral and neurochemical outcomes produced by equal yoked uncontrollable/inescapable tailshocks (ISs). The prelimbic cortex is known to play a key role in mediating the protective effects of control. The concepts of act/outcome learning and control seem similar, and act/outcome learning is mediated by a circuit involving the prelimbic cortex and posterior dorsomedial striatum (DMS). Thus, we tested the involvement of the DMS in the protective effect of ES, in rats. First, we examined Fos immunoreactivity in both the DMS and dorsolateral striatum (DLS) after ES and yoked IS. We then investigated the effect of blocking DMS or DLS N-methyl-d-aspartate receptors with the specific antagonist D-(-)-2-amino-5-phosphopentanoic acid (D-AP5) on the release of dorsal raphe nucleus serotonin (5-HT) during ES, as well as on the level of anxiety produced by the ES experience 24 h later. ES, but not yoked IS, produced a large increase of Fos activity in the DMS. Consistent with the Fos data, D-AP5 in the DMS, but not in the DLS, prevented the inhibition of dorsal raphe nucleus 5-HT release normally produced by ES. Furthermore, D-AP5 administered into the DMS before ES, but not into the DLS, increased anxiety 24 h later, leading to levels similar to those produced by IS. These results suggest that, as with appetitive act/outcome contingency learning, the protective effects of behavioral control over a stressor require the DMS.
机译：可控/可逃避的尾击（ESs）不会产生由相同的轭不可控/不可逃避的尾击（ISs）产生的行为和神经化学结果。已知前肢皮层在介导控制的保护作用中起关键作用。行为/结果学习和控制的概念似乎相似，并且行为/结果学习是由涉及前缘皮层和后背纹状体（DMS）的回路介导的。因此，我们在大鼠中测试了DMS参与ES保护作用的过程。首先，我们检查了ES和轭合IS后DMS和背外侧纹状体（DLS）中的Fos免疫反应性。然后，我们研究了用特定的拮抗剂D-（-）-2-氨基-5-磷酸戊酸（D-AP5）阻断DMS或DLS N-甲基-d-天冬氨酸受体对背phe核5-羟色胺释放的影响（ 5-HT）在ES期间以及ES在24小时后产生的焦虑水平。 ES，而不是带轭的IS，在DMS中产生了大量的Fos活性。与Fos数据一致，DMS中的D-AP5（但不是DLS中的D-AP5）阻止了ES通常产生的背ra核5-HT释放的抑制。此外，D-AP5在ES之前施用到DMS中，而不是在DLS中施用，在24小时后增加了焦虑，导致其水平类似于IS产生的水平。这些结果表明，与具有竞争性的行为/结果应急知识一样，对应激源进行行为控制的保护作用也需要DMS。

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