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首页> 外文期刊>The European Journal of Neuroscience >Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons.
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Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons.

机译：抑癌M受体β在伤害性感觉神经元的特定子集中的表达。

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摘要

Oncostatin M belongs to the interleukin-6 family of cytokines and acts as a multifunctional cytokine during murine embryogenesis and in inflammatory reactions. Although it has been demonstrated that oncostatin M has biological activities on many types of cells, including hepatocytes, dermal fibroblasts and endothelial cells, the roles of oncostatin M in the murine peripheral nervous system remain unclear. Here, we investigated the expression of specific beta-subunit of oncostatin M receptor in the dorsal root ganglia of adult mice. In the adult dorsal root ganglia, beta-subunit of oncostatin M receptor was exclusively expressed in small-sized neurons. Approximately 13% of total dorsal root ganglia neurons in mice contained beta-subunit of oncostatin M receptor. The double-immunofluorescence method revealed that approximately 28% of beta-subunit of oncostatin M receptor-positive neurons contained TrkA immunoreactivity, 63% expressed Ret immunoreactivity and 58% bound isolectin B4. No neuropeptides, including substance P and calcitonin gene-related peptide, were contained in the neurons. In addition, all beta-subunit of oncostatin M receptor-positive neurons expressed both vanilloid receptor 1 and P2X3 purinergic receptor. These neurons projected to the inner portion of lamina II in the dorsal horn of spinal cord and the dermis of skin. Seven days after sciatic nerve axotomy, the expression of beta-subunit of oncostatin M receptor was down-regulated in the lumbar dorsal root ganglia of the injured side. Our study demonstrated that beta-subunit of oncostatin M receptor was expressed in both cell bodies and processes of nonpeptidergic nociceptive neurons in adult mice, suggesting that oncostatin M may affect the nociceptive function of the neurons through the modulation of vanilloid receptor 1 and P2X3 expression.
机译：抑癌素M属于白细胞介素6家族的细胞因子，在鼠胚发生和炎症反应中充当多功能细胞因子。尽管已经证明，抑癌素M对许多类型的细胞具有生物学活性，包括肝细胞，真皮成纤维细胞和内皮细胞，但是抑癌素M在鼠外周神经系统中的作用仍不清楚。在这里，我们调查了成年小鼠背根神经节中抑癌素M受体特异性β亚基的表达。在成人背根神经节中，抑瘤素M受体的β亚基仅在小型神经元中表达。小鼠的整个背根神经节神经元中约有13％含有抑瘤素M受体的β亚基。双重免疫荧光法显示，制抑素M受体阳性神经元的β-亚单位中约28％含有TrkA免疫反应，63％的Ret免疫反应和58％的结合异凝集素B4。神经元中未包含任何神经肽，包括P物质和降钙素基因相关肽。另外，制瘤素M受体阳性神经元的所有β亚基均表达类香草酸受体1和P2X3嘌呤能受体。这些神经元投射到脊髓背角和皮肤真皮的层II的内部。坐骨神经切断后7天，在受伤侧的腰背根神经节中，抑癌素M受体的β-亚基的表达下调。我们的研究表明，成年小鼠中的抑癌素M受体的β亚基在细胞体和非肽能感受伤害性神经元的过程中均有表达，这表明抑癌素M可能通过调节类香草素受体1和P2X3的表达来影响神经元的伤害感受功能。

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