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首页> 外文期刊>The European Journal of Neuroscience >Preshaping and continuous evolution of motor cortical representations during movement preparation.
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Preshaping and continuous evolution of motor cortical representations during movement preparation.

机译：运动准备过程中运动皮层表示的预成形和连续演变。

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While a goal-directed movement is prepared, motor cortical neurons selectively change their activity in relation to prior information about movement direction. Only little is known, however, about the neuronal representation of partial information about this parameter. We investigated this question by training monkeys in a multidirectional centre-out pointing task. A preparatory signal provided prior information about one, two or three possible adjacent targets, thus manipulating the level of certainty about movement direction. After a 1-s delay, the response signal specified one of the precued targets to indicate the actual movement to be performed. Based on the directional tuning curves of individual motor cortical neurons determined during the reaction time interval, we constructed distributions of the population activation (DPAs), which we were then able to estimate as well during the preparatory period. We found that these distributions were preshaped by prior information, with peaks of activationcentred over the range of precued movement directions. These peaks sharpened as the response signal approached, and shifted to the specified movement direction subsequent to that signal. Wider ranges of precued movement directions were represented by broader DPAs. Trials in which monkeys produced short reaction times were characterized by narrower distributions than trials with long reaction times. Our study thus provides evidence for (i) a graded preshaping of the neuronal population representation of movement direction by partial information about this parameter, and (ii) the continuous evolution of the preshaped population representation during the preparatory period towards movement initiation.
机译：在准备定向运动时，运动皮质神经元相对于有关运动方向的先验信息有选择地改变其活动。然而，关于该参数的部分信息的神经元表示知之甚少。我们通过在多方向中心向外指向任务中训练猴子来调查此问题。预备信号提供了有关一个，两个或三个可能的相邻目标的先验信息，从而操纵了有关运动方向的确定性水平。延迟1秒后，响应信号会指定一个预先设定的目标，以指示要执行的实际运动。根据在反应时间间隔内确定的单个运动皮层神经元的方向性调谐曲线，我们构建了种群激活（DPA）的分布，然后我们可以在准备期间进行估算。我们发现，这些分布是由先验信息预成形的，其激活峰值在预定的运动方向范围内居中。这些峰值随着响应信号的接近而锐化，并在该信号之后移至指定的移动方向。较宽的DPA代表了较大范围的预定移动方向。与长反应时间的试验相比，猴子产生短反应时间的试验的分布范围更窄。因此，我们的研究提供了以下证据：（i）通过有关该参数的部分信息来对运动方向的神经元群体表示进行分级预塑形;以及（ii）在预备阶段朝运动开始的过程中，预成型群体表示的连续演变。

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