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首页> 外文期刊>The European Journal of Neuroscience >Age-related changes in the dynamics of human albino visual pathways.
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Age-related changes in the dynamics of human albino visual pathways.

机译：人类白化病视觉通路动力学中与年龄相关的变化。

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A deficiency of melanin in the retinal pigment epithelium, which regulates the development of neural retina, leads to chiasmal misrouting such that the uncrossed pathway (to the ipsilateral hemisphere) is reduced relative to the crossed pathway (to the contralateral hemisphere). This study examines age-related changes in the flash and pattern appearance visual evoked potentials (VEP) of human albinos. Scalp recorded cortical VEPs to flash (FVEP) and pattern appearance stimulation were recorded in 58 albino (8 months to 60 years) and 34 normal subjects (4-55 years). VEPs were analysed by amplitude and latency. The contralateral hemisphere FVEP amplitude decreased with age in albino subjects, as in both hemispheres in normals. However, the ipsilateral hemisphere FVEP amplitude was significantly lower in young albino subjects, initially giving a marked interhemispheric asymmetry, but this normalized with age. Significant interhemispheric FVEP latency asymmetries were not observed. The contralateral pattern appearance VEP latency in albino subjects decreased with age, as in both hemispheres in normals; the ipsilateral latency increased significantly with age. Significant interhemispheric pattern appearance VEP amplitude asymmetries were not observed. These novel and unexpected observations indicate significant age-related changes in the retinocortical pathways of the human albino. These changes have implications for our understanding of development and plasticity of the central visual pathways.
机译：视网膜色素上皮中黑色素的缺乏，调节了神经视网膜的发育，导致chiasmal错误路由，使得相对于交叉途径（到达对侧半球）的未交叉途径（到达同侧半球）减少了。这项研究检查了人类白化病患者的闪光和图案外观视觉诱发电位（VEP）中与年龄相关的变化。在58名白化病患者（8个月至60岁）和34名正常受试者（4至55岁）中记录了头皮记录的皮质VEP闪烁（FVEP）和模式外观刺激。通过振幅和潜伏期分析VEP。白化病患者的对侧半球FVEP振幅随着年龄的增长而下降，就像正常人的两个半球一样。然而，在年轻的白化病患者中，同侧半球的FVEP幅度明显较低，最初具有明显的半球间不对称性，但随着年龄的增长而恢复正常。没有观察到明显的半球间FVEP潜伏期不对称性。白化病患者的对侧模式出现VEP潜伏期随着年龄的增长而降低，就像正常人的两个半球一样。同侧潜伏期随年龄增长而显着增加。没有观察到明显的半球形图案外观VEP振幅不对称性。这些新颖和出乎意料的观察结果表明，人类白化病的视网膜皮质途径中与年龄有关的重大变化。这些变化对我们对中央视觉通路的发展和可塑性的理解具有影响。

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