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首页> 外文期刊>The European Journal of Neuroscience >Central nervous system neurons acquire mast cell products via transgranulation.
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Central nervous system neurons acquire mast cell products via transgranulation.

机译：中枢神经系统神经元通过转粒获得肥大细胞产物。

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Resting and actively degranulating mast cells are found on the brain side of the blood-brain barrier. In the periphery, exocytosis of mast cell granules results in the release of soluble mediators and insoluble granule remnants. These mast cell constituents are found in a variety of nearby cell types, acquired by fusion of granule and cellular membranes or by cellular capture of mast cell granule remnants. These phenomena have not been studied in the brain. In the current work, light and electron microscopic studies of the medial habenula of the dove brain revealed that mast cell-derived material can enter neurons in three ways: by direct fusion of the granule and plasma membranes (mast cell and neuron); by capture of insoluble granule remnants and, potentially, via receptor-mediated endocytosis of gonadotropin-releasing hormone, a soluble mediator derived from the mast cell. These processes result in differential subcellular localization of mast cell material in neurons, including free in the neuronalcytoplasm, membrane-bound in granule-like compartments or in association with small vesicles and the trans-Golgi network. Capture of granule remnants is the most frequently observed form of neuronal acquisition of mast cell products and correlates quantitatively with mast cells undergoing piecemeal degranulation. The present study indicates that mast cell-derived products can enter neurons, a process termed transgranulation, indicating a novel form of brain-immune system communication.
机译：在血脑屏障的大脑侧发现了肥大细胞，它们处于静止状态并积极地脱粒。在外周，肥大细胞颗粒的胞吐作用导致可溶性介质和不溶性颗粒残留物的释放。这些肥大细胞成分存在于各种附近的细胞类型中，可通过颗粒与细胞膜的融合或肥大细胞颗粒残留物的细胞捕获获得。这些现象尚未在大脑中研究。在当前的工作中，对鸽子大脑内侧半支气管的光镜和电镜研究表明，肥大细胞来源的物质可以通过三种方式进入神经元：通过颗粒和质膜（肥大细胞和神经元）的直接融合;通过捕获不溶性颗粒残留物，并有可能通过促性腺激素释放激素（一种肥大细胞衍生的可溶性介体）的受体介导的内吞作用。这些过程导致肥大细胞材料在神经元中的亚细胞局部定位，包括在神经细胞质中游离，膜结合在颗粒状区室中或与小囊泡和反高尔基体网络相关。颗粒残留物的捕获是肥大细胞产物神经元获取的最常观察到的形式，并且与经历零碎脱粒的肥大细胞定量相关。本研究表明，肥大细胞衍生的产物可以进入神经元，这一过程称为“转粒”，表明脑免疫系统通讯的一种新形式。

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