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首页> 外文期刊>The European Journal of Neuroscience >Age-dependent changes in projections from locus coeruleus to hippocampus dentate gyrus and frontal cortex.
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Age-dependent changes in projections from locus coeruleus to hippocampus dentate gyrus and frontal cortex.

机译：从蓝斑到海马齿状回和额叶皮层的投影的年龄依赖性变化。

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Age-dependent changes in noradrenergic innervations of the hippocampal dentate gyrus (DG) and the frontal cortex (FC) have been studied in male F344 rats. The projections from the nucleus locus coeruleus (LC) to DG or FC with advancing age (from 7 to 27 months) in rats have been quantified by electrophysiological and immunohistochemical methods. In the electrophysiological study, we observed that the percentage of LC neurons activated antidromically by electrical stimulation (P-index) of DG or FC decreased with age. We found that the percentage of LC neurons showing multiple antidromic latencies (M-index), which suggests axonal branching of individual LC neurons, increased markedly between 15 and 17 months in DG or FC. In DG, the M-index increased steadily between 15 and 24 months. In contrast, the increased M-index in FC was maintained until 24 months. The increased M-index in both targets declined at 27 months. These results suggest that LC neurons give rise to axonal branching following the loss of projections to DG or FC with age. In the immunohistochemical study, the density of dopamine-beta-hydroxylase-positive axonal varicosities was measured in molecular, granule cell and polymorphic layers of DG. The density in the polymorphic layer significantly decreased in the earlier stage of ageing (7-19 months), whilst the density in the molecular and granule cell layers decreased in the later stage (27 months). These findings suggested that a layer-specific decline occurred with age in the noradrenergic axon terminals in DG.
机译：在雄性F344大鼠中研究了海马齿状回（DG）和额叶皮质（FC）的去甲肾上腺素能神经支配的年龄依赖性变化。已通过电生理和免疫组织化学方法定量了大鼠年龄从7岁到27个月从脑核蓝核（LC）到DG或FC的预测。在电生理研究中，我们观察到，DG或FC的电刺激（P指数）可抗性地激活LC神经元的百分比随着年龄的增长而降低。我们发现，在DG或FC中，LC神经元表现出多重抗躯体潜伏期（M指数）的百分比显着增加了15到17个月之间，表明单个LC神经元的轴突分支。在DG中，M指数在15到24个月之间稳定增长。相比之下，FC中M指数的升高一直维持到24个月。两个目标中增加的M指数在27个月时下降。这些结果表明，随着年龄的增长，对DG或FC的预测丧失，LC神经元会引起轴突分支。在免疫组织化学研究中，在DG的分子，颗粒细胞和多态层中测量了多巴胺-β-羟化酶阳性轴突静脉曲张的密度。在老化的早期阶段（7-19个月），多晶型层的密度显着下降，而在后期阶段（27个月），分子和颗粒细胞层的密度下降。这些发现表明，DG的去甲肾上腺素能轴突末端随着年龄的增长发生了特定层下降。

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