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首页> 外文期刊>The European Journal of Neuroscience >Homeostatic control of the excitation-inhibition balance in cortical layer 5 pyramidal neurons.
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Homeostatic control of the excitation-inhibition balance in cortical layer 5 pyramidal neurons.

机译：皮质5层锥体神经元的兴奋抑制平衡的稳态控制。

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摘要

Homeostatic regulation in the brain is thought to be achieved through a control of the synaptic strength by close interactions between excitation and inhibition in cortical circuits. We recorded in a layer 5 pyramidal neuron of rat cortex the composite response to an electrical stimulation of various layers (2-3, 4 or 6). Decomposition of the global conductance change in its excitatory and inhibitory components permits a direct measurement of excitation-inhibition (E-I) balance. Whatever the stimulated layer was, afferent inputs led to a conductance change consisting of 20% excitation and 80% inhibition. Changing synaptic strengths in cortical networks by using a high-frequency of stimulation (HFS) protocol or a low-frequency of stimulation (LFS) protocol (classically used to induce long-term potentiation or long-term depression at the synaptic level) were checked in order to disrupt this balance. Application of HFS protocols in layers 2-3, 4 or 6, or of LFS protocols in layer 4 induced, respectively, long-term paralleled increases or long-term paralleled decreases in E and I which did not change the E-I balance. LFS protocols in layers 2-3 or 6 decreased E but not I and disrupted the balance. It is proposed that regulatory mechanisms might be mainly sustained by recurrent connectivity between excitatory and inhibitory neuronal circuits and by modulation of shunting GABA(A) inhibition in the layer 5 pyramidal neuron.
机译：大脑中的稳态调节被认为是通过控制皮层回路中的兴奋与抑制之间的紧密相互作用来控制突触强度来实现的。我们在大鼠皮质的第5层锥体神经元中记录了对各层（2-3、4或6）的电刺激的复合反应。分解其兴奋性和抑制性成分中的总电导率变化可以直接测量激发-抑制（E-I）平衡。无论受刺激的层是什么，传入的输入都会导致电导变化，包括20％的激励和80％的抑制。检查通过使用高频刺激（HFS）协议或低频刺激（LFS）协议（通常用于在突触水平上诱导长期增强或长期抑制）来改变皮质网络中的突触强度。为了破坏这种平衡。在2-3、4或6层中应用HFS协议，或在4层中应用LFS协议，分别导致E和I的长期并行增加或长期并行的减少，这并没有改变E-I平衡。 2-3或6层中的LFS协议降低了E，但没有降低I，并破坏了平衡。有人提出，调节机制可能主要由兴奋性和抑制性神经回路之间的经常性连接以及对第5层锥体神经元中分流GABA（A）抑制的调节来维持。

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