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首页> 外文期刊>The European Journal of Neuroscience >Acetylcholine-mediated axon-glia signaling in the developing insect olfactory system.
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Acetylcholine-mediated axon-glia signaling in the developing insect olfactory system.

机译：在发育中的昆虫嗅觉系统中乙酰胆碱介导的轴突神经胶质信号传导。

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摘要

In the olfactory system of the sphinx moth Manduca sexta, migration of neuropil glial cells is triggered by olfactory receptor axons and depends on intraglial Ca(2+) signaling. It is not known, however, how receptor axons and glial cells communicate and whether Ca(2+) signaling is a consequence of this communication. We studied Ca(2+) increases in glial cells in vivo and in situ, evoked by electrical stimulation of olfactory receptor axons in pupae and by odor stimulation of receptor neurons in adult moths. Axonal activity leads to Ca(2+) increases in neuropil glial cells that are blocked by nicotinic acetylcholine receptor antagonists and can be mimicked by acetylcholine and carbachol application. In addition, Ca(2+) transients were abolished by removal of external Ca(2+) and blockage of voltage-gated Ca(2+) channels. During development, acetylcholine-mediated Ca(2+) signaling could first be elicited at stage 6, the time when neuropil glial cells start to migrate. Glial migration was reduced after injection of nicotinic antagonists into pupae. The results show that Ca(2+) signaling can be induced by acetylcholine release from olfactory receptor axons, which activates nicotinic acetylcholine receptors and leads to voltage-gated Ca(2+) influx. The results further suggest that cholinergic signaling in the olfactory system is required for glial cell migration in Manduca.
机译：在狮身人面蛾蛾的嗅觉系统中，嗅觉受体轴突触发神经纤维胶质细胞的迁移，并取决于神经胶质内Ca（2+）信号传导。但是，尚不知道受体轴突和神经胶质细胞如何通讯以及Ca（2+）信号传导是否是这种通讯的结果。我们研究了Ca（2+）在体内和原位的神经胶质细胞中的增加，由electrical中的嗅觉受体轴突的电刺激和成年蛾中受体神经元的气味刺激引起。轴突活性导致神经烟样胶质细胞中的Ca（2+）增加，该细胞被烟碱乙酰胆碱受体拮抗剂所阻断，并且可以被乙酰胆碱和卡巴胆碱的应用所模仿。此外，通过消除外部Ca（2+）和电压门控Ca（2+）通道的阻塞，取消了Ca（2+）瞬变。在开发过程中，乙酰胆碱介导的Ca（2+）信号传导可能首先在第6阶段引发，这是神经毛细胞胶质细胞开始迁移的时间。烟p拮抗剂注入p后，胶质迁移减少。结果表明，Ca（2+）信号可以被嗅觉受体轴突中的乙酰胆碱释放诱导，从而激活烟碱乙酰胆碱受体并导致电压门控的Ca（2+）大量涌入。结果进一步表明，嗅觉系统中的胆碱能信号传导是曼杜卡胶质细胞迁移所必需的。

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