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首页> 外文期刊>The European Journal of Neuroscience >Preservation of visual cortical function following retinal pigment epithelium transplantation in the RCS rat using optical imaging techniques.
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Preservation of visual cortical function following retinal pigment epithelium transplantation in the RCS rat using optical imaging techniques.

机译：使用光学成像技术在RCS大鼠视网膜色素上皮移植后保留视觉皮质功能。

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The aim of this study was to determine the extent of cortical functional preservation following retinal pigment epithelium (RPE) transplantation in the Royal College of Surgeons (RCS) rat using single-wavelength optical imaging and spectroscopy. The cortical responses to visual stimulation in transplanted rats at 6 months post-transplantation were compared with those from age-matched untreated dystrophic and non-dystrophic rats. Our results show that cortical responses were evoked in non-dystrophic rats to both luminance changes and pattern stimulation, whereas no response was found in untreated dystrophic animals to any of the visual stimuli tested. In contrast, a cortical response was elicited in most of the transplanted rats to luminance changes and in many of those a response was also evoked to pattern stimulation. Although the transplanted rats did not respond to high spatial frequency information we found evidence of preservation in the cortical processing of luminance changes and low spatial frequency stimulation. Anatomical sections of transplanted rat retinas confirmed the capacity of RPE transplantation to rescue photoreceptors. Good correlation was found between photoreceptor survival and the extent of cortical function preservation determined with optical imaging techniques. This study determined the efficacy of RPE transplantation to preserve visual cortical processing and established optical imaging as a powerful technique for its assessment.
机译：这项研究的目的是使用单波长光学成像和光谱法确定皇家外科医生学院（RCS）大鼠视网膜色素上皮（RPE）移植后皮质功能保存的程度。将移植后6个月移植大鼠对视觉刺激的皮质反应与年龄匹配的未营养不良和非营养不良大鼠的皮质反应进行了比较。我们的结果表明，在非营养不良的大鼠中诱发了皮质对亮度变化和模式刺激的反应，而在未治疗的营养不良的动物中未发现对所测试的任何视觉刺激有反应。相反，在大多数移植的大鼠中，皮质对亮度的变化产生了反应，而在许多大鼠中，皮层的反应也引起了模式刺激。尽管移植的大鼠对高空间频率信息无反应，但我们发现在皮层亮度变化和低空间频率刺激的皮层处理中有保存证据。移植大鼠视网膜的解剖切片证实了RPE移植能够抢救感光细胞。发现光感受器的存活与通过光学成像技术确定的皮层功能保存程度之间具有良好的相关性。这项研究确定了RPE移植保留视觉皮层加工的功效，并建立了光学成像作为对其进行评估的有力技术。

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