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首页> 外文期刊>The European Journal of Neuroscience >Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibility.
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Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibility.

机译：大鼠血清素转运蛋白缺乏改善了抑制控制，但没有行为灵活性。

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Impulsivity and aggression have been suggested to inversely correlate with central serotonin (5-HT) levels in a trait-like manner. However, this relationship is far from straightforward. In the present study we addressed the effect of lifelong reduced or absent serotonin transporter (SERT) function, which is associated with constitutively increased extracellular 5-HT levels, on impulsivity and aggression. We used unique SERT knockout rats in a resident-intruder test, five-choice serial reaction time task and serial reversal learning task to assay aggression, inhibitory control and behavioural flexibility, respectively. Homozygous SERT knockout rats (SERT( -/-)) displayed reduced aggression and improved inhibitory control, but unchanged behavioural flexibility. The behavioural phenotype of heterozygous SERT knockout rats (SERT( +/-)) was not different from that of wild-type controls in any of the behavioural paradigms. We determined monoamine (metabolite) tissue levels in the medial prefrontal cortex, orbitofrontal cortex, lateral hypothalamus, raphe nuclei and cerebrospinal fluid, and found that the 5-HT levels, but not other monoamine tissue levels, were reduced in SERT( -/-) rats. In addition, the 5-hydroxyindoleacetic acid (5-HIAA)/5-HT ratio in cerebrospinal fluid was increased in these rats. In conclusion, our data show that the absence of the SERT affects aggression and inhibitory control, but not behavioural flexibility, characteristics that may reflect the trait-like consequences of constitutive changes in central 5-HT levels.
机译：已提出冲动性和攻击性以特征性方式与中央5-羟色胺（5-HT）水平成反比。但是，这种关系远非直截了当。在本研究中，我们研究了5-羟色胺转运蛋白（SERT）终生减少或缺失的功能，与功能性细胞外5-HT水平升高有关，对冲动和攻击性有影响。我们在驻地-入侵者测试，五项选择连续反应时间任务和连续逆向学习任务中使用了独特的SERT基因敲除大鼠来分别测试攻击性，抑制性控制和行为灵活性。纯合SERT基因敲除大鼠（SERT（-/-））表现出减少的攻击性和改善的抑制控制，但行为灵活性不变。杂合性SERT基因敲除大鼠的行为表型（SERT（+/-））在任何行为范式中均与野生型对照无差异。我们确定了内侧前额叶皮层，眶额叶皮层，下丘脑外侧，睑裂核和脑脊液中的单胺（代谢物）组织水平，并发现SERT中5-HT的水平降低了，但其他单胺组织的水平却没有降低。 ）大鼠。另外，这些大鼠中脑脊髓液中的5-羟基吲哚乙酸（5-HIAA）/ 5-HT比值增加。总之，我们的数据表明，缺少SERT会影响攻击性和抑制性控制，但不会影响行为灵活性，这些特征可能反映了中枢5-HT水平组成性改变的特征样后果。

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