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Mitochondria and the hallmarks of cancer

机译:线粒体和癌症的标志

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Mitochondria have traditionally been viewed as the powerhouse of the cell, where they serve, amongst other functions, as a major source of ATP generation. More recently, mitochondria have also been shown to have active roles in a variety of other processes, including apoptotic cell death and inflammation. Here we review the various ways in which mitochondrial functions affect cancer. Although there are many diverse types of cancer, hallmarks have been defined that are applicable to most cancer types. We provide an overview of how mitochondrial functions affect some of these hallmarks, which include evasion of cell death, de-regulated bioenergetics, genome instability, tumour-promoting inflammation and metastasis. In addition to discussing the underlying mitochondrial roles in each of these processes, we also highlight the considerable potential of targeting mitochondrial functions to improve cancer treatment.
机译:线粒体传统上一直被视为细胞的强大力量,在其中,细胞除其他功能外,还作为ATP产生的主要来源。最近,线粒体还显示出在多种其他过程中发挥积极作用,包括凋亡性细胞死亡和炎症。在这里,我们回顾了线粒体功能影响癌症的各种方式。尽管存在多种癌症类型,但已定义了适用于大多数癌症类型的标志。我们概述了线粒体功能如何影响这些特征中的一些特征,包括逃避细胞死亡,失调的生物能学,基因组不稳定,促进肿瘤的炎症和转移。除了讨论每个过程中潜在的线粒体作用外,我们还强调了靶向线粒体功能改善癌症治疗的巨大潜力。

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