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首页> 外文期刊>The FEBS journal >Structural and functional aspects of unique type IV secretory components in the Helicobacter pylori cag-pathogenicity island. [Review]
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Structural and functional aspects of unique type IV secretory components in the Helicobacter pylori cag-pathogenicity island. [Review]

机译：幽门螺杆菌cag致病岛中独特的IV型分泌成分的结构和功能方面。 [评论]

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摘要

Helicobacter pylori cytotoxin-associated gene-pathogenicity island (cagPAI) is responsible for the secretion of the CagA effector through a type IV secretion system (T4SS) apparatus, as well as of peptidoglycan and possibly other not yet identified factors. Twenty-nine different polypeptide chains are encoded by this cluster of genes, although only some of them show a significant similarity with the constitutive elements of well characterized secretion systems from other bacteria. The other cagPAI components represent almost unique proteins in this scenario. The majority of the T4SS include approximately fifteen components, taking into account either the transmembrane complex subunits, ATPases or substrate factors. The composition of the cagPAI is very complex: it includes proteins most likely involved at different levels in the pilus assembly, stabilization and processing of secreted substrate, as well as regulatory particles possibly involved in the control of the entire apparatus. Despite recent findings with respect to components that play a role in the interaction with the host cell, the function of several cagPAI proteins remains unclear or unknown. This is particularly true for those that represent unique members with no clear similarity to those of other T4SS and no obvious evidence of involvement in the secretion of CagA or induction of pro-inflammatory responses. We summarize what is known about these accessory components, both from a molecular and structural point of view, as well as their putative physiological role. Copyright 2011 The Authors Journal compilation Copyright 2011 FEBS.
机译：幽门螺杆菌细胞毒素相关基因致病岛（cagPAI）负责通过IV型分泌系统（T4SS）装置分泌CagA效应子，以及肽聚糖和其他可能尚未鉴定的因子。该基因簇编码了29条不同的多肽链，尽管只有其中一些显示出与来自其他细菌的特征明确的分泌系统的组成元件具有显着相似性。在这种情况下，其他cagPAI成分几乎代表唯一的蛋白质。考虑到跨膜复合物亚基，ATPase或底物因子，大多数T4SS包含约15个组分。 cagPAI的组成非常复杂：它包含最可能以不同水平参与菌毛组装，分泌底物的稳定和加工的蛋白质，以及可能参与整个设备控制的调节颗粒。尽管关于在与宿主细胞的相互作用中起作用的组分的最新发现，但是几种cagPAI蛋白的功能仍然不清楚或未知。对于那些代表独特成员且与其他T4SS没有明显相似性且没有明显证据参与CagA分泌或促炎反应的证据，尤其如此。我们从分子和结构的角度总结了有关这些辅助成分的已知信息，以及它们可能的生理作用。版权所有2011 The Authors Journal汇编版权所有2011 FEBS。

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