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Conserved systems and functional genomic assessmentof nociception

机译:伤害感受的保守系统和功能基因组学评估

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摘要

Chronic pain represents a significant public health concern and currenttherapies do not adequately meet patient needs. With the advent of genomictechnologies, pain researchers have begun to identify key loci associatingwith human pain diseases, and these data are instructing thedevelopment of next generation analgesics. Although human geneticsefforts have been effective, complementary approaches, including functionalgenomics, may provide additional insight into pain genetics and helpidentify additional new drug targets. In the present review, we discuss theuse of fruit fly systems biology combined with mammalian genetics toaccelerate the discovery of novel pain genes and candidate drug targets.
机译:慢性疼痛代表着重大的公共卫生问题,当前的治疗方法不能充分满足患者的需求。随着基因组技术的出现,疼痛研究人员已经开始确定与人类疼痛疾病相关的关键基因座,这些数据正在指导下一代止痛药的发展。尽管人类遗传努力一直有效,但包括功能基因组学在内的补充方法可能会提供有关疼痛遗传学的更多见解,并有助于确定其他新的药物靶标。在本综述中,我们讨论了果蝇系统生物学与哺乳动物遗传学相结合的使用,以加速发现新的疼痛基因和候选药物靶标。

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