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首页> 外文期刊>The FEBS journal >What does S-palmitoylation do to membrane proteins?
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What does S-palmitoylation do to membrane proteins?

机译：S-棕榈酰化对膜蛋白有什么作用？

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摘要

S-palmitoylation is post-translational modification, which consists in the addition of a CI6 acyl chain to cytosolic cysteines and which is unique amongst lipid modifications in that it is reversible. It can thus, like phosphorylation or ubiquitination, act as a switch. While palmitoylation of soluble proteins allows them to interact with membranes, the consequences of palmitoylation for transmembrane proteins are more enigmatic. We briefly review the current knowledge regarding the enzymes responsible for palmitate addition and removal. We then describe various observed consequences of membrane protein palmitoylation. We propose that the direct effects of palmitoylation on transmembrane proteins, however, might be limited to four non-mutually exclusive mechanistic consequences: alterations in the conformation of transmembrane domains, association with specific membrane domains, controlled interactions with other proteins and controlled interplay with other post-translational modifications.
机译：S-棕榈酰化是翻译后修饰，其包括在胞质半胱氨酸中添加CI6酰基链，并且在脂质修饰中是独特的，因为它是可逆的。因此，它可以像磷酸化或泛素化一样充当开关。虽然可溶性蛋白的棕榈酰化使它们能够与膜相互作用，但棕榈酰化对跨膜蛋白的影响却更加令人费解。我们简要回顾了有关负责棕榈酸酯添加和去除的酶的当前知识。然后，我们描述了膜蛋白棕榈酰化的各种观察到的结果。我们建议，棕榈酰化对跨膜蛋白的直接影响可能仅限于四个非互斥的机制性后果：跨膜结构域构象的改变，与特定膜结构域的结合，与其他蛋白质的受控相互作用以及与其他蛋白质的受控相互作用翻译后修饰。

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