Dietary vitamin E, brain redox status and expression of Alzheimer's disease-relevant genes in rats

Gaedicke Sonja; Zhang Xiangnan; Huebbe Patricia; Boesch-Saadatmandi Christine; Lou Yijia; Wiswedel Ingrid; Gardemann Andreas; Frank Jan; Rimbach Gerald

首页> 外文期刊>The British Journal of Nutrition >Dietary vitamin E, brain redox status and expression of Alzheimer's disease-relevant genes in rats

【24h】

Dietary vitamin E, brain redox status and expression of Alzheimer's disease-relevant genes in rats

机译：饮食中维生素E，脑氧化还原状态和阿尔茨海默氏病相关基因的表达

获取原文

获取原文并翻译 | 示例

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Oxidative stress is one of the major pathological features of Alzheimer's disease (AD). Here, we investigated whether dietary vitamin E (VE) depletion may induce adverse effects and supplementation with l-tocopherol (lT) may result in beneficial effects on redox status and the regulation of genes relevant in the pathogenesis of AD in healthy rats. Three groups of eight male rats each were fed diets with deficient ( < 1 mg lT equivalents/kg diet), marginal (9 mg lT equivalents/kg diet) or sufficient (18 mg lT equivalents/kg diet) concentrations of natural-source VE for 6 months; a fourth group was fed the VE-sufficient diet fortified with lT (total VE, 146 mg lT equivalents/kg diet). Feeding of the experimental diets dose dependently altered lT concentrations in the cortex and plasma. No significant changes in F2-isoprostane concentrations, activities of antioxidative enzymes (total superoxide dismutase, Se-dependent glutathione peroxidase) and concentrations of glutathione or the expression of AD-relevant genes were observed. In this non-AD model, depletion of VE did not induce adverse effects and supplementation of lT did not induce positive effects on the parameters related to the progression of AD.

机译：氧化应激是阿尔茨海默氏病（AD）的主要病理特征之一。在这里，我们调查了饮食中维生素E（VE）的消耗是否会引起不良反应，而补充1-生育酚（lT）可能会对氧化还原状态和健康大鼠AD发病机理相关基因的调节产生有益影响。三组，每组八只雄性大鼠，其饮食中的天然来源VE含量不足（<1 mg lT当量/ kg饮食），边际（9 mg lT当量/ kg饮食）或足够（18 mg lT当量/ kg饮食） 6个月;第四组饲喂富含lT的VE足够的饮食（总VE，146 mg lT当量/ kg饮食）。实验饮食的喂养剂量依赖性地改变了皮质和血浆中的IT浓度。没有观察到F2-异前列腺素浓度，抗氧化酶活性（总超氧化物歧化酶，Se依赖性谷胱甘肽过氧化物酶）和谷胱甘肽浓度或AD相关基因表达无明显变化。在这种非AD模型中，VE的耗竭不会引起不利影响，而补充IT则不会对与AD进展相关的参数产生积极影响。

著录项

来源
《The British Journal of Nutrition》 |2009年第3期|共9页
作者
Gaedicke Sonja; Zhang Xiangnan; Huebbe Patricia; Boesch-Saadatmandi Christine; Lou Yijia; Wiswedel Ingrid; Gardemann Andreas; Frank Jan; Rimbach Gerald;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类营养卫生、食品卫生;
关键词

相似文献

外文文献
中文文献
专利

1. Dietary vitamin E, brain redox status and expression of Alzheimer's disease-relevant genes in rats [J] . Gaedicke Sonja, Zhang Xiangnan, Huebbe Patricia, The British Journal of Nutrition . 2009,第3期

机译：饮食中维生素E，脑氧化还原状态和阿尔茨海默氏病相关基因的表达
2. Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. [J] . Shahani N, Subramaniam S, Wolf T, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2006,第22期

机译：在器官型海马切片中靶向表达阿尔茨海默氏病相关的tau构建体后，Tau聚集和进行性神经元变性在脊柱密度和形态无变化的情况下。
3. Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: Relevance to Alzheimer's disease pathogenesis [J] . Trovato A., Siracusa R., Di Paola R., Neurotoxicology . 2016,第Null期

机译：云芝在大鼠脑中对细胞应激反应和脂质体A4表达的氧化还原调节：与阿尔茨海默氏病发病机理的关系
4. Impact of dietary vitamin E and selenium source on body vitamin E and selnium status and performance of nursery pigs [C] . H. Yang, D.C. Mahan, D.A. Hill, Annual Meeting of the American Association of Swine Veterinarians . 2007

机译：膳食维生素E和硒源对苗圃维生素E和硒的影响的影响
5. The Effect of Dietary Fat on Fatty Acid Composition, Gene Expression and Vitamin Status in Pre-Ruminant Calves. [D] . Tsai, Chia-Yu. 2016

机译：日粮脂肪对反刍前犊牛脂肪酸组成，基因表达和维生素状态的影响。
6. Tau Aggregation and Progressive Neuronal Degeneration in the Absence of Changes in Spine Density and Morphology after Targeted Expression of Alzheimers Disease-Relevant Tau Constructs in Organotypic Hippocampal Slices [O] . Neelam Shahani, Srinivasa Subramaniam, Tobias Wolf, 2006

机译：Tau聚集和进行性神经元变性缺乏器官型海马切片中的阿尔茨海默氏病相关Tau构建体的目标表达后脊柱密度和形态的变化。
7. Six practical diets were formulated to contain 2.6 (the basal diet), 48.9, 95.5, 189.83, 382.4, 779.53 mg/kg vitamin C diet. After 8 weeks of feeding, growth performance, antioxidant status, and innate immunity of juvenile pufferfish were analyzed. Results showed that specific growth rate and protein efficiency ratio in fish fed diets supplemented with vitamin C were significantly higher than in fish fed the control diet. Dietary vitamin C significantly up-regulated the expression levels of growth hormone receptors and Insulin-like growth factor. Blood cell numbers and respiratory burst activity were enhanced in fish fed vitamin C diet. Serum alkaline phosphatase, glutamic-pyruvic transaminase, and glutamic-oxaloacetic transaminase activity were significantly influenced by the dietary vitamin C levels. Fish fed diets supplemented with vitamin C showed increased hepatic superoxide dismutase, glutathione peroxidase, and catalase activity, but decreased malondialdehyde activity. In addition, we found that dietary vitamin C can significantly up-regulate the expression levels of immune-related genes (HSP70, HSP90, BAFF, TNF-α and IL-6) in liver. These results indicate that dietary vitamin C can significantly influence growth performance, antioxidant status, and innate immunity of pufferfish. [O] . Cheng C-H, Liang H-Y., Guo Z-X., 2017

机译：配制了六种实用饮食，分别含有2.6（基础饮食），48.9、95.5、189.83、382.4、779.53 mg / kg维生素C饮食。喂食8周后，分析了幼崽河豚的生长性能，抗氧化剂状态和先天免疫力。结果表明，补充维生素C的鱼饲料的比生长速率和蛋白质效率比显着高于对照组的鱼。饮食中的维生素C显着上调了生长激素受体和胰岛素样生长因子的表达水平。喂鱼的维生素C饮食可提高血细胞数量和呼吸爆发活性。饮食中的维生素C水平显着影响血清碱性磷酸酶，谷氨酸-丙酮酸转氨酶和谷氨酸-草酰乙酸转氨酶的活性。补充维生素C的鱼饲料日粮中肝超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶活性增加，但丙二醛活性降低。此外，我们发现饮食中的维生素C可以显着上调肝脏中免疫相关基因（HSP70，HSP90，BAFF，TNF-α和IL-6）的表达水平。这些结果表明，饮食中的维生素C可以显着影响河豚的生长性能，抗氧化状态和先天免疫力。
8. Increased Expression of the Chemokines CXCL1 and MIP-1a by Resident Brain Cells Precedes Neutrophil Infiltration in the Brain Following Prolonged Soman-Induced Status Epilepticus in Rats [R] . Johnson, E. A., Dao, T. L., Guignet, M. A., 2011

机译：驻留脑细胞增加趋化因子CXCL1和mIp-1a的表达在大鼠中长期梭曼诱导的癫痫持续状态后中性粒细胞浸润

Dietary vitamin E, brain redox status and expression of Alzheimer's disease-relevant genes in rats

摘要

著录项

相似文献

相关主题

期刊订阅