Transport Behavior of Amino Acid across Charged Mosaic Membrane

Takashi Fukuda; Akira Yamauchi

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Transport Behavior of Amino Acid across Charged Mosaic Membrane

机译：氨基酸跨带电马赛克膜的转运行为

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Several characteristics on a charged mosaic membrane with parallel arrays of different negative and positive charges were investigated through transport studies. In particular, the transport behaviors of three different amino acids (GluNa, Arg, and Ala), known as amphoteric electrolytes, were examined in contrast to those of the simple electrolytes (KCl and LiCl). From an analysis of the data of the volume flux and salt flux, although preferential amino acid transport across the charged mosaic membrane was observed, the extent of the permeability was les than that of simple salt. Among amino acids, GluNa with almost complete dissociation indicated the maximum permeability. A conductance study indicated that the transport behavior were dependent on the ionic states in aqueous solution. It was inferred that amino acids with apparent zero net charges have transport behaviors different from a nonelectrolyte, such as sucrose.

机译：通过运输研究，研究了带有带负电荷和正电荷的平行阵列的带电镶嵌膜的几个特性。特别地，与简单电解质（KCl和LiCl）相比，研究了两种不同的氨基酸（GluNa，Arg和Ala）的运输行为，称为两性电解质。从体积通量和盐通量的数据分析，尽管观察到氨基酸优先通过带电的镶嵌膜转运，但是通透性的程度比简单盐少。在氨基酸中，几乎完全解离的GluNa表示最大的渗透性。电导研究表明，传输行为取决于水溶液中的离子态。推断具有明显零净电荷的氨基酸具有不同于非电解质例如蔗糖的转运行为。

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《Bulletin of the Chemical Society of Japan》 |2000年第12期|共4页
作者
Takashi Fukuda; Akira Yamauchi;
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中图分类化学;化学工业;
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1. Transport Behavior of Amino Acid across Charged Mosaic Membrane [J] . Takashi Fukuda, Akira Yamauchi Bulletin of the Chemical Society of Japan . 2000,第12期

机译：氨基酸跨带电马赛克膜的转运行为
2. Mutations of charged amino acids in or near the transmembrane helices of the second membrane spanning domain differentially affect the substrate specificity and transport activity of the multidrug resistance protein MRP1 (ABCC1). [J] . Haimeur A, Conseil G, Deeley RG, Molecular pharmacology. . 2004,第6期

机译：第二个跨膜结构域的跨膜螺旋中或附近的带电氨基酸突变差异地影响多重耐药蛋白MRP1（ABCC1）的底物特异性和转运活性。
3. pH and Ionic Strength Effects on Amino Acid Transport through Au-Nanotubule Membranes Charged with Self-Assembled Monolayers [J] . Jie-Ren Ku, Shih-Ming Lai, Nazar Ileri, The journal of physical chemistry, C. Nanomaterials and interfaces . 2007,第7期

机译：pH和离子强度对通过自组装单层膜的金纳米管膜氨基酸转运的影响。
4. Synthesis, Properties and Complexation Behavior of Positively Charged Peptide Ribonucleic Acids with Amino Linkages in the Backbone Structure (aza-PRNA) [C] . Nobuya Sawa, Seiji Sakamoto, Cheng Yang Japanese peptide symposium . 2010

机译：正电荷肽核糖核酸的合成，性质和络合行为在骨架结构中氨基键合（AZA-PRNA）
5. Functional consequences of charged amino acid substitutions in and around transmembrane helices in the third membrane spanning domain of MRP1. [D] . Situ, Donna. 2004

机译：MRP1第三跨膜结构域中跨膜螺旋内部和周围带电氨基酸取代的功能后果。
6. Incorporation of a charged amino acid into the membrane-spanning domain blocks cell surface transport but not membrane anchoring of a viral glycoprotein. [O] . G A Adams, J K Rose 1985

机译：将带电荷的氨基酸掺入跨膜结构域可阻断细胞表面运输但不会阻断病毒糖蛋白的膜锚定。
7. Incorporation of a charged amino acid into the membrane-spanning domain blocks cell surface transport but not membrane anchoring of a viral glycoprotein. [O] . Adams, G A, Rose, J K 1985

机译：将带电荷的氨基酸掺入跨膜结构域可阻断细胞表面运输，但不会阻断病毒糖蛋白的膜锚定。

Transport Behavior of Amino Acid across Charged Mosaic Membrane

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