Synthesis of Fragment A Derivative of an Antibiotic, Nosiheptide

Kazuyuki Umemura; Hirofumi Noda; Juji Yoshimura; Akihito Konn; Tasuchika Yonezawa; Chung-gi Shin

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Synthesis of Fragment A Derivative of an Antibiotic, Nosiheptide

机译：抗生素Nosiheptide片段A衍生物的合成

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Two 4-ethoxycarbonyl thiazolyl groups were introduced into 2- and 5-positions of 3-hydroxypyridine in 8 steps using 5-cyano-3-hydroxypyridine (2) as the staring materials. The pyridine derivative obtained in the last step was converted to a fragment A derivative (21) by stepwise introduction of the 2-substituted 4-thiazolyl group into the 6-position. The total yield for the formation of 21 via 14 steps was 7.6%

机译：以5-氰基-3-羟基吡啶（2）为起始原料，分8步将两个4-乙氧基羰基噻唑基引入3-羟基吡啶的2-和5-位。通过将2-取代的4-噻唑基逐步引入6-位，将在最后一步中获得的吡啶衍生物转化为片段A衍生物（21）。通过14个步骤形成21个步骤的总收率为7.6％

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《Bulletin of the Chemical Society of Japan》 |1998年第6期|共6页
作者
Kazuyuki Umemura; Hirofumi Noda; Juji Yoshimura; Akihito Konn; Tasuchika Yonezawa; Chung-gi Shin;
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正文语种 eng
中图分类化学;化学工业;
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1. Synthesis of Fragment A Derivative of an Antibiotic, Nosiheptide [J] . Kazuyuki Umemura, Hirofumi Noda, Juji Yoshimura, Bulletin of the Chemical Society of Japan . 1998,第6期

机译：抗生素Nosiheptide片段A衍生物的合成
2. TOTAL SYNTHESIS OF NOSIHEPTIDE - SYNTHESIS OF THIAZOLE FRAGMENTS [J] . Koerberple K., Massiot G. Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 1995,第4期

机译：总鼻肽的合成-噻唑片段的合成。
3. Synthesis of the 2,3,4-trisubstituted indole fragments of nosiheptide and glycothiohexide [J] . David J. Bentley, John Fairhurst, Peter T. Gallagher, Organic & biomolecular chemistry . 2004,第5期

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4. Synthesis and properties of 1,3-dioxo-1H-inden-2(3H)-ylidene fragment and (3-(dicyanomethylene)-5,5-dimethylcyclohex-1-enyl)vinyl fragment containing derivatives of azobenzene for holographic recording materials [C] . Elmars Zarins, Valdis Kokars, ris Ozols, Holography: Advances and modern trends II . 2011

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5. Syntheses of fused pyrroloheterocycles, isatins, approach towards the indole fragment of nosiheptide and a base-mediated formation of 3-hydroxycarbazoles . [D] . Gorugantula, Sobha Priyadarshini. 2009

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6. Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus [O] . Nina M. Haste, Wdee Thienphrapa, Dan N. Tran, -1

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7. 1H and 13C NMR assignments of the thiopeptide antibiotic nosiheptide. [O] . U. MOCEK, L.-C. CHEN, P. J. KELLER, 1989

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Synthesis of Fragment A Derivative of an Antibiotic, Nosiheptide

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