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首页> 外文期刊>The British Journal of Nutrition >Improvement of the metabolic syndrome profile by soluble fibre - guar gum - in patients with type 2 diabetes: a randomised clinical trial.
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Improvement of the metabolic syndrome profile by soluble fibre - guar gum - in patients with type 2 diabetes: a randomised clinical trial.

机译：2型糖尿病患者通过可溶性纤维-瓜尔胶改善代谢综合征的特征：一项随机临床试验。

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A diet rich in fibre seems to protect against the metabolic syndrome (MetS), but there is scarce information about the role of fibre intake in patients with the MetS and diabetes. The aim of the present study was to evaluate the effects of soluble fibre from partially hydrolysed guar gum (PHGG) on the MetS and cardiovascular risk factors in patients with type 2 diabetes. In the present randomised controlled clinical trial, forty-four patients with type 2 diabetes (males 38.6%, age 62 (sd 9) years, diabetes duration 14.2 (sd 9.6) years) and the MetS underwent clinical, laboratory and dietary evaluations at baseline, 4 and 6 weeks. All patients followed their usual diet and the intervention group (n 23) received an additional 10 g/d of PHGG. In the intervention group, waist circumference (WC), glycated Hb (HbA1c), 24 h urinary albumin excretion (UAE) and serum trans-fatty acids (FA) were reduced in comparison with baseline after 4 and 6 weeks: WC 103.5 (sd 9.5) to 102.1 (sd 10) to 102.3 (sd 9.7) cm; HbA1c 6.88 (sd 0.99) to 6.64 (sd 0.94) to 6.57 (sd 0.84) %; 24 h UAE 6.8 (interquartile range 3.0-17.5) to 4.5 (interquartile range 3.0-10.5) to 6.2 (interquartile range 3.0-9.5) mg; trans-FA 71 (interquartile range 46-137) to 67 (interquartile range 48-98) to 57 (interquartile range 30-110) mg/l (P<0.05 for all). The only change in the control group was weight reduction: 77.0 (sd 13.5) to 76.2 (sd 13.3) to 76.1 (sd 13.4) kg (P=0.005). Other MetS components (blood pressure, TAG, HDL-cholesterol, fasting plasma glucose), total and LDL-cholesterol, C-reactive protein and endothelin-1 did not change in either group. In patients with type 2 diabetes and the MetS, the addition of PHGG to the usual diet improved cardiovascular and metabolic profiles by reducing WC, HbA1c, UAE and trans-FA.
机译：富含纤维的饮食似乎可以预防代谢综合症（MetS），但是关于MetS和糖尿病患者摄入纤维的作用的信息很少。本研究的目的是评估部分水解瓜耳胶（PHGG）的可溶性纤维对2型糖尿病患者MetS和心血管危险因素的影响。在本随机对照临床试验中，四十四例2型糖尿病患者（男性38.6％，年龄62（标准偏差9）岁，糖尿病病程14.2（标准偏差9.6）岁）和MetS在基线时接受了临床，实验室和饮食评估，第4和第6周。所有患者均遵循常规饮食，干预组（n = 23）每天接受10 g /日的PHGG。在干预组中，与基线相比，干预组在第4周和第6周后腰围（WC），糖化Hb（HbA1c），24 h尿白蛋白排泄（UAE）和血清反式脂肪酸（FA）降低​​：WC 103.5（sd 9.5）至102.1（sd 10）至102.3（sd 9.7）厘米; HbA1c 6.88（sd 0.99）至6.64（sd 0.94）至6.57（sd 0.84）％; 24小时阿拉伯联合酋长国6.8（四分位间距3.0-17.5）至4.5（四分位间距3.0-10.5）至6.2（四分位间距3.0-9.5）mg;反式FA 71（四分位数范围46-137）至67（四分位数范围48-98）至57（四分位数范围30-110）mg / l（全部P <0.05）。对照组的唯一变化是体重减轻：从77.0（sd 13.5）降至76.2（sd 13.3）至76.1（sd 13.4）千克（P = 0.005）。其他MetS组分（血压，TAG，HDL-胆固醇，空腹血糖），总胆固醇和LDL-胆固醇，C反应蛋白和内皮素-1均未改变。在患有2型糖尿病和MetS的患者中，在日常饮食中添加PHGG可通过减少WC，HbA1c，UAE和trans-FA改善心血管和代谢状况。

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