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首页> 外文期刊>The British Journal of Nutrition >Birth weight alters the response to postnatal high-fat diet-induced changes in meat quality traits and skeletal muscle proteome of pigs.
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Birth weight alters the response to postnatal high-fat diet-induced changes in meat quality traits and skeletal muscle proteome of pigs.

机译：出生体重改变了猪出生后高脂饮食引起的肉质性状和骨骼肌蛋白质组变化的反应。

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摘要

Low birth weight (LBW) exerts persistent effects on the growth and development of offspring. The present study was conducted to test the hypothesis that LBW alters the response of pigs to high-fat (HF) diet-induced changes in meat quality and skeletal muscle proteome. Normal-birth weight (NBW) and LBW piglets were fed a control diet or a HF diet from weaning to slaughter at 110 kg body weight. Most of the meat quality traits were influenced by LBW. Meat quality analysis revealed that LBW piglets had a greater ability to deposit intramuscular lipids than their heavier littermates when fed a HF diet. Increased shear force, lower pH45 min and drip loss were observed in the skeletal muscle of LBW piglets compared with NBW piglets. Proteomic analysis revealed forty-six differentially expressed proteins in the skeletal muscle of LBW and NBW piglets fed the control diet or HF diet. These proteins play a central role in cell structure and motility, glucose and energy metabolism, lipid metabolism, and cellular apoptosis, as well as stress response. Of particular interest is the finding that LBW altered the response to HF diet-induced changes in the expression of proteins related to stress response (heat shock protein) and glucose and energy metabolism (pyruvate kinase, phosphoglycerate mutase, enolase and triosephosphate isomerase). Taken together, our findings revealed that the HF diet-induced changes in the expression of glucose and energy metabolism-related proteins varied between NBW and LBW piglets, which provides a possible mechanism to explain higher intramuscular fat store in LBW pigs when fed a HF diet.
机译：低出生体重（LBW）对后代的生长发育产生持续影响。进行本研究以检验以下假设的假设：LBW改变猪对高脂饮食诱导的肉质和骨骼肌蛋白质组变化的反应。从断奶至屠宰后，以体重110千克的体重从正常体重（NBW）和体重不足的仔猪喂饲对照饲料或HF饲料。大部分肉质性状都受到LBW的影响。肉品质量分析显示，饲喂HF日粮时，LBW仔猪比其较重的同窝仔仔具有更大的肌内脂质沉积能力。与NBW仔猪相比，LBW仔猪骨骼肌的剪切力增加，pH 45 min 降低和滴落损失。蛋白质组学分析显示，在饲喂对照饮食或HF饮食的LBW和NBW仔猪的骨骼肌中有46种差异表达的蛋白质。这些蛋白质在细胞结构和运动，葡萄糖和能量代谢，脂质代谢，细胞凋亡以及应激反应中起着核心作用。特别令人感兴趣的发现是，LBW改变了对HF饮食诱导的与应激反应（热激蛋白），葡萄糖和能量代谢（丙酮酸激酶，磷酸甘油酸变位酶，烯醇酶和磷酸三糖异构酶）相关的蛋白质表达变化的反应。综上所述，我们的发现表明，在NBW和LBW仔猪之间，HF日粮诱导的葡萄糖和能量代谢相关蛋白表达的变化是不同的，这提供了一个可能的机制来解释当饲喂HF日粮时LBW猪的肌肉内脂肪储存量较高。

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