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Review of Prescribing Practices for Intermittent Bolus Administration of Morphine

机译:间歇性吗啡给药吗啡处方实践的回顾

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Background: Several changes to medication safety practices were proposed in a pediatric hospital, including changing the period of patient observation after administration of opioids and limiting the availability of various concentrations of morphine in the patient care unit.Objective: To document and review postoperative pain management for children on a surgical ward, specifically with regard to intermittent IV bolus administration of morphine, to help in assessing the impact of the proposed nursing practice changes.Methods: Data were collected from records for narcotics and controlled drugs for the surgical ward over a 3-month period (April to June 2006). For each patient, data had been recorded for up to 7 consecutive days after surgery. A patient's data were included in the review if he or she had received at least 2 doses of morphine by IV bolus, except for the review of weight-based dosing pattern (mg/kg), for which all patients who had received at least one dose of IV morphine were included.Results: Charts for 193 patients were audited. Of these, 163 patients (84.5%) had recieved up to 0.1 mg/kg per dose, and 53 (27.5%) had received only one dose of morphine. Among patients who received more than one dose, the median dose was 0.080 mg/kg on day 1, with a decrease by day 5 to 0.065 mg/kg. Most patients received morphine over the first 2 days after surgery. The median time elapsed between doses was 4.3 h on day 1 and 6.2 h on day 2. Of the 1020 doses included in the analysis, most (801 [78.5%]) were 4 mg or less.Conclusion: The intermittent administration of IV bolus doses of morphine at the study hospital followed common standards for the treatment of postoperative pain. Most doses were no more than 4 mg. On the basis of this information, only 2-mg vials of morphine are now stocked on the ward. The hospital's change in monitoring practices will increase the surveillance of patients receiving IV bolus doses of morphine.
机译:背景:儿科医院提出了一些药物安全措施的变更建议,包括改变服用阿片类药物后的患者观察时间,并限制患者护理部门使用不同浓度的吗啡的有效性。目的:记录和审查术后疼痛的管理针对在外科病房中的儿童,特别是在间歇性静脉推注吗啡给药方面,以帮助评估提议的护理实践变化的影响。方法:从3天内从外科病房的麻醉药品和管制药物记录中收集数据月期间(2006年4月至2006年6月)。对于每位患者,手术后最多连续7天记录数据。如果他或她通过静脉推注接受了至少2剂吗啡剂量,则该患者的数据包括在该评价中,但基于体重的给药方式(mg / kg)的评价除外,对于所有患者,至少接受过一次吗啡结果:对193例患者的图表进行了审核。在这些患者中,有163名患者(84.5%)接受的最高剂量为每剂0.1 mg / kg,而53名患者(27.5%)仅接受了一剂吗啡。在接受多于一种剂量的患者中,第1天的中位剂量为0.080 mg / kg,到第5天下降至0.065 mg / kg。大多数患者在手术后的前两天接受吗啡。两次给药之间的中位时间在第1天为4.3 h,在第2天为6.2 h。在分析中包括的1020剂中,大多数(801 [78.5%])剂量为4 mg或更少。结论:静脉推注的间歇性给药研究医院的吗啡剂量遵循术后疼痛的通用标准。大多数剂量不超过4毫克。根据这些信息,病房现在只储存了2毫克的吗啡小瓶。医院监测方法的变化将加强对接受静脉推注吗啡剂量的患者的监测。

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