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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Physical Compatibility and Chemical Stability of Ketamine-Morphine Mixtures in Polypropylene Syringes
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Physical Compatibility and Chemical Stability of Ketamine-Morphine Mixtures in Polypropylene Syringes

机译：氯丁胺吗啡混合物在聚丙烯注射器中的物理相容性和化学稳定性

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Background: Small amounts of ketamine administered with a narcotic can help to reduce both requirements for and potential adverse effects of the opioid. The use of ketamine in conjunction with morphine has become popular with the Acute Pain Service of the author's hospital. However, the only reported stability data that have been found for this combination stored in syringes were for 6 days at room temperature.Objective: To conduct a compatibility and stability study with the ultimate aim of extending the current expiry date for the concentrations of ketamine and morphine combinations used at the authors institution and thus to allow batch production of mixtures of these drugs without increasing wastage.Methods: Commercial solutions of ketamine (50 mg/mL) and morphine sulphate (50 mg/mL) were combined and further diluted with 0.9% sodium chloride to final concentrations of ketamine 2 mg/mL and morphine 2, 5, or 10 mg/mL; the resulting mixtures were packaged in polypropylene syringes. The syringes were stored at either 23deg C or 5deg C for 91 days. The following physical compatibility parameters were monitored: clarity, colour, and pH. Chemical stability was determined with a validated stability-indicating high-performance liquid chromatography system.Results: Over the 91 days, all solutions remained clear and colourless, and the pH did not change significantly. The concentration of each drug in the various solutions remained above 98% of the original concentration for both storage conditions for the duration of the study.Conclusions: Solutions of ketamine (2 mg/mL) combined with morphine (2, 5, or 10 mg/mL) were physically compatible and chemically stable for 91 days when diluted with normal saline, packaged in polypropylene syringes, and stored at either 23deg C or 5deg C.
机译：背景：少量氯胺酮与麻醉药一起使用可有助于减少阿片类药物的需求量和潜在的不良反应。氯胺酮与吗啡联合使用已在作者医院的急性疼痛服务中流行。然而，唯一发现的这种组合的稳定性数据是在注射器中保存的，在室温下保存了6天。目的：进行相容性和稳定性研究，其最终目的是延长氯胺酮和氯胺酮的当前有效期。吗啡组合在作者机构使用，因此可以批量生产这些药物的混合物而不会增加浪费。方法：将氯胺酮（50 mg / mL）和硫酸吗啡（50 mg / mL）的商业溶液合并，并进一步用0.9稀释氯化钠至氯胺酮2 mg / mL和吗啡2、5或10 mg / mL的最终浓度;将所得混合物包装在聚丙烯注射器中。将注射器在23℃或5℃下保存91天。监测以下物理相容性参数：透明度，颜色和pH。结果：在91天之内，所有溶液均保持澄清无色，并且pH值未发生明显变化，从而确定了化学稳定性。在整个研究过程中，两种储存条件下每种溶液中每种药物的浓度均保持在原始浓度的98％以上。结论：氯胺酮（2 mg / mL）与吗啡（2、5或10 mg）的溶液/ mL）在生理盐水中相容并在用生理盐水稀释后化学稳定91天，包装在聚丙烯注射器中，并在23°C或5°C下保存。

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