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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Uveitis associated with Primary Angiitis of the Central Nervous System.
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Uveitis associated with Primary Angiitis of the Central Nervous System.

机译：与中枢神经系统原发性血管炎相关的葡萄膜炎。

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摘要

BACKGROUND: In Primary Angiitis of the Central Nervous System (PACNS), disease is typically limited to the brain and spinal cord although other organs may be affected. Uveitis is occasionally seen in systemic vasculitides but is not a recognized manifestation of PACNS. We describe two patients who developed PACNS following the onset of uveitis. CASE DESCRIPTIONS: Case 1--a 47-year-old male suffered multiple TIAs and left pontine stroke shortly after two episodes of diffuse uveitis. A cerbral angiogram demonstrated multiple caliber changes within several intracranial vessels. Cyclophosphamide was added after his stroke occurred during pulse methylprednisolone therapy. Case 2--a 35-year-old male suffered a spinal cord TIA followed by hemispheric and brainstem infarctions two months after an episode of uveitis and Bell's palsy treated with oral prednisone. A cerebral angiogram demonstrated multiple caliber changes within several intracranial vessels. He was successfully treated with oral prednisone and cyclophosphamide. CONCLUSIONS: Uveitis should be considered a recognized feature of PACNS. Combination immunosuppressive therapy with prednisone and cyclophosphamide may be necessary for successful treatment.
机译：背景：在中枢神经系统原发性血管炎（PACNS）中，疾病可能仅限于大脑和脊髓，尽管其他器官也可能受到影响。葡萄膜炎偶尔见于全身性血管炎，但不是公认的PACNS表现。我们描述了两名在葡萄膜炎发作后发展为PACNS的患者。病例描述：病例1 –一名47岁的男性在两次弥漫性葡萄膜炎发作后不久遭受了多次TIA并左桥脑中风。脑血管造影显示颅内多个血管内多个口径变化。在脉搏甲基强的松龙治疗期间中风后，添加了环磷酰胺。案例2-一名35岁的男性在葡萄膜炎和贝尔麻痹发作后两个月接受口服泼尼松治疗，脊髓TIA继发半球和脑干梗塞。脑血管造影显示颅内多个血管内多个口径变化。他已成功接受口服泼尼松和环磷酰胺治疗。结论：葡萄膜炎应被认为是PACNS的公认特征。泼尼松和环磷酰胺联合免疫抑制治疗可能是成功治疗的必要条件。

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