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Simultaneous EEG-fMRI in human epilepsy.

机译:在人类癫痫中同时进行脑电图。

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摘要

Electroencephalography (EEG) has been used to study and characterize epilepsy for decades, but has a limited ability to localize epileptiform activity to a specific brain region. With recent technological advances, high-quality EEG can now be recorded during functional magnetic resonance imaging (fMRI), which characterizes brain activity through local changes in blood oxygenation. By combining these techniques, the specific timing of interictal events can be identified on the EEG at millisecond resolution and spatially localized with fMRI at millimeter resolution. As a result, simultaneous EEG-fMRI provides the opportunity to better investigate the spatiotemporal mechanisms of the generation of epileptiform activity in the brain. This article discusses the technical considerations and their solutions for recording simultaneous EEG-fMRI and the results of studies to date. It also addresses the application of EEG-fMRI to epilepsy in humans, including clinical applications and ongoing challenges.
机译:脑电图(EEG)被用于研究和表征癫痫病已有数十年的历史,但将癫痫样活动定位于特定大脑区域的能力有限。随着最新技术的发展,现在可以在功能磁共振成像(fMRI)期间记录高质量的脑电图,该功能通过血液氧合的局部变化来表征大脑活动。通过组合这些技术,可以在毫秒级分辨率下在EEG上确定发作间隔事件的具体时间,并在毫米级分辨率下使用fMRI在空间上进行定位。结果,同时进行的EEG-fMRI提供了更好地研究大脑中癫痫样活动产生的时空机制的机会。本文讨论了同时记录EEG-fMRI的技术注意事项及其解决方案以及迄今为止的研究结果。它还解决了脑电图功能磁共振成像在人类癫痫中的应用,包括临床应用和持续的挑战。

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