Elevated levels of coagulation factor viii in patients with venous leg ulcers

CriadoP.R.; AlaviA.; KirsnerR.S.

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Elevated levels of coagulation factor viii in patients with venous leg ulcers

机译：静脉曲张性溃疡患者凝血因子VII水平升高

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Chronic venous disease affects millions of people around the world. Venous valvular incompetencies and venous reflux, often a result of outflow obstruction are important contributors to venous disease. The prevalence of thrombophilia is increased in patients with chronic venous insufficiency (CVI). The recognition of underlying thrombophilia particularly in young patients opens new avenues in the management and prevention plan. We emphasize on the consideration of workup for coagulopathy, especially factor VIII deficiency in young patients with venous disease. We report 3 patients with chronic leg ulcers and high levels of FVIII:C activity in plasma and other associated thrombophilic factors. We highlight the need to get a workup done for thrombophilia in young patients with recurrent and chronic leg ulcers related to venous insufficiency or livedoid vasculopathy. Further studies with larger sample sizes are required to define the definite indications for the thrombophilia workups.

机译：慢性静脉疾病影响世界各地数百万人。静脉瓣膜功能不全和静脉回流，通常是流出道阻塞的结果，是导致静脉疾病的重要原因。患有慢性静脉功能不全（CVI）的患者血栓形成的患病率增加。对潜在血栓形成的认识，特别是在年轻患者中，为管理和预防计划开辟了新途径。我们强调要考虑针对凝血病的检查，尤其是年轻静脉疾病患者的VIII因子缺乏症。我们报告了3例患有慢性腿溃疡的患者，血浆中FVIII：C和其他相关血栓形成因素的活性较高。我们强调有必要对年轻患者进行血栓形成检查，这些患者患有与静脉功能不全或活体血管病变有关的复发性和慢性腿溃疡。需要进行更大样本量的进一步研究来确定血栓形成检查的确切指征。

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《The international journal of lower extremity wounds》 |2014年第2期|共5页
作者
CriadoP.R.; AlaviA.; KirsnerR.S.;
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正文语种 eng
中图分类外科学;
关键词
coagulopathy; factor VIII; venous leg ulcer;

机译：凝血病;凝血因子VIII;下肢静脉溃疡;

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专利

1. Elevated levels of coagulation factor viii in patients with venous leg ulcers [J] . CriadoP.R., AlaviA., KirsnerR.S. The international journal of lower extremity wounds . 2014,第2期

机译：静脉曲张性溃疡患者凝血因子VII水平升高
2. In patients with deep-vein thrombosis elevated levels of factor VIII correlate only with von Willebrand factor but not other endothelial cell-derived coagulation and fibrinolysis proteins. [J] . Bombeli T, Jutzi M, De Conno E, Blood coagulation & fibrinolysis: an international journal in haemostasis and thrombosis . 2002,第7期

机译：在患有深静脉血栓形成的患者中，VIII因子水平升高仅与von Willebrand因子相关，而与其他内皮细胞衍生的凝血和纤溶蛋白无关。
3. Elevated plasma factor VIII levels in patients with venous thrombosis - Constitutional risk factor or secondary epiphenomenon? [J] . RyanK., ODonnellJ.S. Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2012,第2期

机译：静脉血栓形成患者血浆VIII因子水平升高-体质危险因素还是继发性表象现象？
4. Inactiwatlon of Animal Factor VIII by human Factor VIII Inhibitors: Inwestigation of Plasma from Patients with Inhibitors in congenital Hemophilia I and from Patients with acquired Hemophilia A [C] . V. Aumann, G. Lutze (Jr.), G. Lutze (Sen.), Hemophilie-Symposion . 2003

机译：人为因子VIII抑制剂的动物因子VIII的乙酰丁酮：先天性血友病药中抑制剂患者的血浆中的预防
5. A prospective, multicentre, randomized, controlled clinical investigation of dermagraft in patients with venous leg ulcers. [D] . Al-Muhairi, Amna Suhail. 2004

机译：静脉曲张溃疡患者皮肤移植的前瞻性，多中心，随机对照临床研究。
6. Determinants of increased levels of von Willebrand factor and coagulation factor VIII in patients with venous thrombosis [O] . J.C.J. Eikenboom 2006

机译：静脉血栓形成患者von Willebrand因子和凝血因子VIII水平升高的决定因素
7. Low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and pulmonary emboli/deep venous thromboses in replicate cohorts of patients with hereditary haemorrhagic telangiectasia [O] . Livesey, JA, Manning, RA, Meek, JH, 2012

机译：血清铁水平低与遗传性出血性毛细血管扩张患者重复队列中血浆凝血因子VIII水平升高和肺栓塞/深静脉血栓形成有关

Elevated levels of coagulation factor viii in patients with venous leg ulcers

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