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首页> 外文期刊>The journal of clinical hypertension. >Changes in Aortic Pulse Wave Velocity in Hypertensive Postmenopausal Women: Comparison Between a Calcium Channel Blocker vs Angiotensin Receptor Blocker Regimen
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Changes in Aortic Pulse Wave Velocity in Hypertensive Postmenopausal Women: Comparison Between a Calcium Channel Blocker vs Angiotensin Receptor Blocker Regimen

机译：绝经后高血压妇女主动脉脉搏波速度的变化：钙通道阻滞剂与血管紧张素受体阻滞剂方案的比较

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Postmenopausal women are at greater risk for hypertension-related cardiovascular disease. Antihypertensive therapy may help alleviate arterial stiffness that represents a potential modifiable risk factor of hypertension. This randomized controlled study investigated the difference between an angiotensin receptor blocker and a calcium channel blocker in reducing arterial stiffness. Overall, 125 postmenopausal hypertensive women (age, 61.4±6years; systolic blood pressure/diastolic blood pressure [SBP/DBP], 158±11/92±9mmHg) were randomized to valsartan 320mg±hydrochlorothiazide (HCTZ) (n=63) or amlodipine 10mg±HCTZ (n=62). The primary outcome was carotid-to-femoral pulse wave velocity (PWV) changes after 38weeks of treatment. Both treatments lowered peripheral blood pressure (BP) (-22.9/-10.9mmHg for valsartan and -25.2/-11.7mmHg for amlodipine, P=not significant) and central BP (-15.7/-7.6mmHg for valsartan and -19.2/-10.3mmHg for amlodipine, P<.05 for central DBP). Both treatments similarly reduced the carotid-femoral PWV (-1.9 vs -1.7m/s; P=not significant). Amlodipine was associated with a higher incidence of peripheral edema compared with the valsartan group (77% vs 14%, P<.001). BP lowering in postmenopausal women led to a reduction in arterial stiffness as assessed by PWV measurement. Both regimens reduced PWV to a similar degree after 38weeks of treatment despite differences in central BP lowering, suggesting that the effect of valsartan on PWV is mediated through nonhemodynamic effects.
机译：绝经后妇女罹患高血压相关心血管疾病的风险更高。降压治疗可能有助于减轻动脉僵硬，这代表了潜在的高血压危险因素。这项随机对照研究调查了血管紧张素受体阻滞剂和钙通道阻滞剂在降低动脉僵硬度方面的差异。总体上，将125名绝经后高血压妇女（年龄61.4±6岁;收缩压/舒张压[SBP / DBP]，158±11/92±9mmHg）随机分为缬沙坦320mg±氢氯噻嗪（n = 63）或氨氯地平10mg±HCTZ（n = 62）。主要结果是治疗38周后颈动脉至股动脉脉搏波速度（PWV）的变化。两种治疗均降低了外周血压（BP）（缬沙坦为-22.9 / -10.9mmHg，氨氯地平为-25.2 / -11.7mmHg，P =不显着）和中枢性血压（缬沙坦为-15.7 / -7.6mmHg，-19.2 /-氨氯地平为10.3mmHg，中央DBP为P <.05）。两种治疗方法均类似地降低了颈股PWV（-1.9对-1.7m / s; P =不显着）。与缬沙坦组相比，氨氯地平与周围水肿的发生率更高（77％比14％，P <.001）。通过PWV测量评估，绝经后妇女的BP降低导致动脉僵硬度降低。尽管中枢血压降低存在差异，但两种方案均在治疗38周后将PWV降低至相似的程度，这表明缬沙坦对PWV的作用是通过非血液动力学作用介导的。

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