MR566A AND MR566B, NEW MELANIN SYNTHESIS INHIBITORS PRODUCED BY TRICHODERMA HARZIANUM .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES

Lee CH.; Lee HJ.; Bae KS.; Kho YH.; Chung MC.

首页> 外文期刊>The Journal of Antibiotics: An International Journal >MR566A AND MR566B, NEW MELANIN SYNTHESIS INHIBITORS PRODUCED BY TRICHODERMA HARZIANUM .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES

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MR566A AND MR566B, NEW MELANIN SYNTHESIS INHIBITORS PRODUCED BY TRICHODERMA HARZIANUM .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES

机译：毛滴虫Trichoderma Harzianum生产的新型黑色素合成抑制剂MR566A和MR566B..1。分类法，发酵，分离和生物活性

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New melanin synthesis inhibitors (MR566A and B) and six related known isocyanocyclopentenes were isolated from the fermentation broth of Trichoderma harzianum. The IC50 values of MR566A and B against mushroom tyrosinase were 1.72 and 47 mu M, respectively. They inhibited melanin biosynthesis in B16 melanoma cells with MIC values of 0.1 and 2.2 mu M, respectively. Also isolated from the same culture extract of T. harzianum was a new oxazole (MR93B), which showed no inhibitory activity against mushroom tyrosinase at a concentration of 1,000 mu g/ml. [References: 15]

机译：从哈茨木霉的发酵液中分离出了新的黑色素合成抑制剂（MR566A和B）和六个相关的已知异氰基环戊烯。 MR566A和B对蘑菇酪氨酸酶的IC50值分别为1.72和47μM。它们抑制B16黑色素瘤细胞中MIC值分别为0.1和2.2μM的黑色素生物合成。还从哈茨木霉的相同培养物提取物中分离出了新的恶唑（MR93B），其在浓度为1,000μg / ml时对蘑菇酪氨酸酶没有抑制活性。 [参考：15]

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《The Journal of Antibiotics: An International Journal》 |1997年第6期|共5页
作者
Lee CH.; Lee HJ.; Bae KS.; Kho YH.; Chung MC.;
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正文语种 eng
中图分类药学;药品;
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Dna;

机译：痛风;

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1. MR566A AND MR566B, NEW MELANIN SYNTHESIS INHIBITORS PRODUCED BY TRICHODERMA HARZIANUM .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES [J] . Lee CH., Lee HJ., Bae KS., The Journal of Antibiotics: An International Journal . 1997,第6期

机译：毛滴虫Trichoderma Harzianum生产的新型黑色素合成抑制剂MR566A和MR566B..1。分类法，发酵，分离和生物活性
2. Melanocins A,B and C,New Melanin synthesis inhibitors produced by eupenicillium shearii.I.taxonomy,fermentation,isolation and biological properties [J] . Jong-Pyung Kim, Byoung-Kwon Kim, Bong-Sik Yun, The Journal of Antibiotics: An International Journal . 2003,第12期

机译：黑色素A，B和C，剪切型紫茎泽兰产生的新型黑色素合成抑制剂ii。分类学，发酵，分离和生物学特性
3. PF1092A, B AND C, NEW NONSTEROIDAL PROGESTERONE RECEPTOR LIGANDS PRODUCED BY PENICILLIUM OBLATUM .1. TAXONOMY OF PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES [J] . Tabata Y., Hatsu M., Kurata Y., The Journal of Antibiotics: An International Journal . 1997,第4期

机译：青霉菌产生的新的非甾体孕酮受体PF1092A，B和C.1。生产菌株，发酵，分离和生物活性的分类
4. Effect of fermentation conditions on activity of cellulase produced by Trichoderma viride CE-1 [C] . Liu Qingyu, Wang Xiaowei 2011 International Conference on New Technology of Agricultural Engineering . 2011

机译：发酵条件对木霉CE-1产生的纤维素酶活性的影响
5. Part I. Isolation of natural product inhibitors and synthesis of inhibitors of signal transduction. Part II. Structure-activity relationship for a series of glycosidase inhibitors. [D] . Fraser, Rebecca Dawn. 1993

机译：第一部分：天然产物抑制剂的分离和信号转导抑制剂的合成。第二部分一系列糖苷酶抑制剂的构效关系。
6. Biogenic silver nanoparticles based on trichoderma harzianum: synthesis characterization toxicity evaluation and biological activity [O] . Mariana Guilger, Tatiane Pasquoto-Stigliani, Natália Bilesky-Jose, -1

机译：基于哈茨木霉的生物银纳米颗粒：合成表征毒性评估和生物活性
7. MR566A and MR566B, New Melanin Synthesis Inhibitors Produced by Trichoderma harzianum. I. Taxonomy, Fermentation, Isolation and Biological Activities. [O] . CHOONG HWAN LEE, MYUNG CHUL CHUNG, HO JAE LEE, 1997

机译：MR566A和MR566B，新的黑色素合成抑制剂由Trichoderma Harzianum产生。 I.分类，发酵，分离和生物活性。
8. Isolation, Biosynthesis and Biological Activity of Alkaloids of Tylophora Asthmatica, a Versatile Medicinal Plant [R] . Mulchandani, N. B. 1987

机译：多功能药用植物Tylophora asthmatica生物碱的分离，生物合成和生物活性

MR566A AND MR566B, NEW MELANIN SYNTHESIS INHIBITORS PRODUCED BY TRICHODERMA HARZIANUM .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES

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