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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Valine influences production and complex composition of glycopeptide antibiotic A40926 in fermentations of Nonomuraea sp. ATCC 39727.
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Valine influences production and complex composition of glycopeptide antibiotic A40926 in fermentations of Nonomuraea sp. ATCC 39727.

机译:缬氨酸影响Nonomuraea sp。发酵过程中糖肽抗生素A40926的产生和复杂组成。 ATCC 39727。

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摘要

In actinomycetes the catabolism products of branched chain amino acids provide biosynthetic precursors for the formation of several lipid-containing antibiotics. We have determined in Nonomuraea sp. ATCC 39727 the effect of valine on production of glycopeptide antibiotic A40926, which is a complex of factors structurally differing in fatty acid moieties. Addition of valine to minimal medium increased A40926 production and modified complex composition towards a mono-component. Similar results were also obtained in a rich production medium.
机译:在放线菌中,支链氨基酸的分解代谢产物为形成几种含脂抗生素提供了生物合成的前体。我们已经确定了Nonomuraea sp.。 ATCC 39727缬氨酸对糖肽抗生素A40926产生的影响,这是脂肪酸部分在结构上不同的多种因素。在基本培养基中添加缬氨酸可提高A40926的产量,并使复合物的组成朝单组分方向发展。在丰富的生产介质中也获得了类似的结果。

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