Biotransformation of Bile Acids by Pathogenic Actinomycetes Nocardia otitidiscaviarum and Amycolatopsis sp.Strains

Akira Mukai; Katsukiyo Yazawa; Yuzuru Mikami; Ken-ichi Harada; Udo Grafe

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Biotransformation of Bile Acids by Pathogenic Actinomycetes Nocardia otitidiscaviarum and Amycolatopsis sp.Strains

机译：致病性放线菌诺卡氏菌和链霉菌菌株对胆汁酸的生物转化

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Three sterol-type compounds (compounds 4,5 and 6) were isolated from culture broth of pathogenic Nocardia otitidiscaviarum IFM 0988 and Amycolatopsis sp.IFM 0703 strains which were isolated from Japanese patients.The structures of the compounds were determined by NMR and mass spectrometric analyses.The structural studies indicated that compound 4 is a biotransformation product from cholic acid derivative in a nutrient culture medium constituent by a reductase-type enzyme,and the remaining two compounds 5 and 6 are also biotransformation ones by oxidase-type enzymes.

机译：从日本患者中分离出病原性诺卡氏菌诺卡氏菌IFM 0988和Amycolatopsis sp.IFM 0703菌株的培养液中分离出3种固醇型化合物（化合物4,5和6），并通过NMR和质谱法确定了化合物的结构结构研究表明，化合物4是营养培养基中胆酸衍生物通过还原酶型酶的生物转化产物，其余两种化合物5和6也是氧化酶型酶的生物转化产物。

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《The Journal of Antibiotics: An International Journal》 |2005年第5期|共5页
作者
Akira Mukai; Katsukiyo Yazawa; Yuzuru Mikami; Ken-ichi Harada; Udo Grafe;
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正文语种 eng
中图分类药学;
关键词
Nocardia otitidiscaviarum; Amycolatopsis sp.; biotransformation; cholic acid;

机译：诺卡氏菌;淀粉样变;生物转化;胆酸;

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1. Biotransformation of Bile Acids by Pathogenic Actinomycetes Nocardia otitidiscaviarum and Amycolatopsis sp.Strains [J] . Akira Mukai, Katsukiyo Yazawa, Yuzuru Mikami, The Journal of Antibiotics: An International Journal . 2005,第5期

机译：致病性放线菌诺卡氏菌和链霉菌菌株对胆汁酸的生物转化
2. Pulmonary nocardiosis caused by Nocardia otitidiscaviarum in an adult asthmatic female patient: The presence of acid-fast branching filaments is always significant [J] . Mahgoub A., Gumaa S. A., Joseph M. R. P., South African medical journal: Suid-Afrikaanse tydskrif vir geneeskunde . 2017,第1期

机译：Nocardia Otitidiscaviarum在成人哮喘女性患者中引起的肺伤害伤害：酸快枝丝的存在总是很重要
3. Nocardia otitidiscaviarum あるいはNocardia brasiliensisによる皮膚ノカルジア症の2例 [J] . 中田珠美, 小出まさよ, 斎藤希人, 臨床皮膚科 . 2004,第8期

机译：两例因诺卡氏菌或巴西诺卡氏菌引起的皮肤性心脏病
4. Cloning and Characterization of Rat Bile Salt Export Pump Promoter: Bile Acid Activation Is Mediated Via Farnesoid X Receptor/bile Acid Receptor [C] . N. Balasubramaniyan, F. J. Suchy, M. Ananthanarayanan Falk Symposium . 2003

机译：大鼠胆汁盐出口泵启动子的克隆与表征：胆汁酸活化是通过法呢X受体/胆汁酸受体介导的
5. Enantiomeric bile acids as probes of bile acid biology [D] . Katona, Bryson William 2009

机译：对映体胆汁酸作为胆汁酸生物学探针
6. Molecular study of persistence of Nocardia asteroides and Nocardia otitidiscaviarum strains in patients with long-term nocardiosis. [O] . F Provost, F Laurent, L R Uzcategui, 1997

机译：长期诺卡氏病患者中诺卡氏小行星和诺卡氏菌持久性的持久性的分子研究。
7. Amycolatopsis palatopharyngis sp. nov., a potentially pathogenic actinomycete isolated from a human clinical source [O] . Ying Huang, Mariola Paściak, Zhiheng Liu, 2004

机译：AmycolaTopsis Palatopharyngis SP。 11月。，一种从人类临床来源中分离的潜在致病的放线症
8. Bile Acids and Lipid Metabolism Ii. Essential Role of Bile Acids in Bile Phospholipid Excretion [R] . Entenman, C., Holloway, R. J., Albright, M. L., 1968

机译：胆汁酸和脂质代谢Ii。胆汁酸在胆汁磷脂排泄中的重要作用

Biotransformation of Bile Acids by Pathogenic Actinomycetes Nocardia otitidiscaviarum and Amycolatopsis sp.Strains

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