Chemical Synthesis and Characterization of J46 Peptide, an Atypical Class IIa Bacteriocin from Lactococcus lactis subsp. cremoris J46 Strain.

Lasta S; Fajloun Z; Darbon H; Mansuelle P; Andreotti N; Sabatier JM; Boudabous A; Sampieri F

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Chemical Synthesis and Characterization of J46 Peptide, an Atypical Class IIa Bacteriocin from Lactococcus lactis subsp. cremoris J46 Strain.

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Chemical Synthesis and Characterization of J46 Peptide, an Atypical Class IIa Bacteriocin from Lactococcus lactis subsp. cremoris J46 Strain.

机译：乳酸乳球菌亚种非典型IIa类细菌素J46肽的化学合成和表征。 cremoris J46株。

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Bacteriocin J46 is a 27-residue polypeptide produced by Lactococcus lactis subsp. cremoris J46 in fermented milk. The natural form of J46 (nJ46) exhibits a broad antimicrobial spectrum. Herein, we produced the synthetic form of J46 (sJ46) by solid-phase chemical synthesis. The biochemical and physico-chemical properties of sJ46, as well as its antimicrobial activity, were found to be identical to those of its natural counterpart nJ46. It showed a potent antimicrobial activity against both lactic acid bacteria and other Gram-positive microorganisms. (1)H-NMR conformational analysis of sJ46 indicates that it adopts a flexible random coil structure.

机译：细菌素J46是由乳酸乳球菌亚种产生的27个残基的多肽。发酵乳中的creemoris J46。 J46（nJ46）的天然形式具有广泛的抗菌谱。在这里，我们通过固相化学合成制备了J46（sJ46）的合成形式。发现sJ46的生化和物理化学特性及其抗菌活性与天然对等物nJ46相同。它对乳酸菌和其他革兰氏阳性微生物均显示出有效的抗菌活性。（1）sJ46的1 H-NMR构象分析表明它采用了一种灵活的无规卷曲结构。

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《The Journal of Antibiotics: An International Journal》 |2008年第2期|共5页
作者
Lasta S; Fajloun Z; Darbon H; Mansuelle P; Andreotti N; Sabatier JM; Boudabous A; Sampieri F;
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正文语种 eng
中图分类药学;药品;
关键词
J4; Lactococcus lactis; Peptides; Synthesis; Strain typing; 乳球菌; 乳; 肽类;

机译：J4;Lactococcus lactis;Peptides;Synthesis;Strain typing;乳球菌;乳;肽类;

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1. Chemical Synthesis and Characterization of J46 Peptide, an Atypical Class IIa Bacteriocin from Lactococcus lactis subsp. cremoris J46 Strain. [J] . Lasta S, Fajloun Z, Darbon H, The Journal of Antibiotics: An International Journal . 2008,第2期

机译：乳酸乳球菌亚种非典型IIa类细菌素J46肽的化学合成和表征。 cremoris J46株。
2. Characterization of a Wild, Novel Nisin A-Producing Lactococcus Strain with an L. lactis subsp. cremoris Genotype and an L. lactis subsp. lactis Phenotype, Isolated from Greek Raw Milk [J] . Maria Parapouli, Céline Delbès-Paus, Athanasia Kakouri, Applied and Environmental Microbiology . 2013,第11期

机译：野生的新型乳链菌肽产生乳链菌肽A菌株的表征。 cremoris基因型和乳酸乳亚种。乳酸表型，从希腊原料乳中分离
3. Characterization of a Wild, Novel Nisin A-Producing Lactococcus Strain with an L. lactis subsp. cremoris Genotype and an L. lactis subsp. lactis Phenotype, Isolated from Greek Raw Milk [J] . Maria Parapouli, Céline Delbès-Paus, Athanasia Kakouri, Applied Microbiology . 2013,第11期

机译：野生的新型乳链菌肽产生乳链菌肽A菌株的表征。 cremoris基因型和乳酸乳亚种。乳酸表型，从希腊原料乳中分离
4. Nitrogen metabolic profile of Lactococcus lactis subsp. cremoris strains under stress conditions [C] . R. Fernández-Pérez, L. Díez Aldama, M. González Lázaro, International Conference on Environmental, Industrial and Applied Microbiology . 2014

机译：乳球菌乳酸乳糜液的氮素代谢谱。压力条件下的克雷莫里斯菌株
5. Characterization of the function and interaction of proteins involved in exopolysaccharide synthesis in Streptococcus thermophilus, Streptococcus iniae, and Lactococcus lactis subsp. cremoris. [D] . Cefalo, Angela D. 2012

机译：嗜热链球菌，猪链球菌和乳酸乳球菌亚种胞外多糖合成中蛋白质功能和相互作用的表征。 creemoris。
6. Lactococcin A a new bacteriocin from Lactococcus lactis subsp. cremoris: isolation and characterization of the protein and its gene. [O] . H Holo, O Nilssen, I F Nes 1991

机译：Lactococcin A一种来自乳酸乳球菌亚种的新细菌素。 cremoris：蛋白质及其基因的分离和表征。
7. Chemical Synthesis and Characterization of J46 Peptide, an Atypical Class IIa Bacteriocin from Lactococcus lactis subsp. cremoris J46 Strain [O] . Samar Lasta, Ziad Fajloun, Hervé Darbon, 2008

机译：J46肽的化学合成与表征，来自乳酸乳乳乳乳球菌患者的非典型IIA菌菌。 Cremoris J46应变

Chemical Synthesis and Characterization of J46 Peptide, an Atypical Class IIa Bacteriocin from Lactococcus lactis subsp. cremoris J46 Strain.

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