The first total synthesis of nidulalin A, a dihydroxanthone possessing multiple bioactivities.

Tatsuta K; Yoshihara S; Hattori N; Yoshida S; Hosokawa S

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The first total synthesis of nidulalin A, a dihydroxanthone possessing multiple bioactivities.

机译：尼杜拉林A（具有多种生物活性的二氢黄酮）的首次全合成。

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Nidulalin A (1) was isolated by Kawahara's group from the rice culture of an ascomyce-tous fungus, Emericella nidulans (Eidam) Vuill. var. lata (Thom and Raper) Subram. (anamorph: Aspergillus nidulellus, Samon and W Gams), strain IN-68.1 The structure of nidulalin A (1) was determined by X-ray crystallography and Mosher's method as well as by comparison of CD spectra with known xanthone derivatives.1 In the later studies, nidulalin A (1) was found to possess potent inhibitory activity against DNA topoisomerase II and immunomodula-tory activity.

机译：Nidulalin A（1）是由Kawahara的研究小组从子囊真菌真菌Emericella nidulans（Eidam）Vuill的水稻培养物中分离得到的。变种拉塔（Thom and Raper）Subram。（无性形变体：曲霉，Samon和W Gams），菌株IN-68.1通过X射线晶体学和Mosher方法以及将CD光谱与已知的x吨酮衍生物进行比较，确定了尼杜拉林A（1）的结构。1后来的研究发现，尼杜拉林A（1）具有对DNA拓扑异构酶II的强抑制活性和免疫调节活性。

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《The Journal of Antibiotics: An International Journal》 |2009年第8期|共2页
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Tatsuta K; Yoshihara S; Hattori N; Yoshida S; Hosokawa S;
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机译：尼杜拉林A（具有多种生物活性的二氢黄酮）的首次全合成。
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The first total synthesis of nidulalin A, a dihydroxanthone possessing multiple bioactivities.

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