In vitro evaluation of the antimicrobial activity of HM-242, a novel antiseptic compound.

Okunishi J; Nishihara Y; Maeda S; Ikeda M

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In vitro evaluation of the antimicrobial activity of HM-242, a novel antiseptic compound.

机译：新型抗菌化合物HM-242的体外抗菌活性评估。

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The antimicrobial activities of N(4)-octyl-6,6-dimethyl-N(2)-(4-methylbenzyl)-1,6-dihydro-1,3,5-triazine-2,4-diam ine (HM-242), a novel synthetic compound, were compared with those of chlorhexidine gluconate (CHG). HM-242 was a more potent microbicide than CHG in vitro; however, its minimal inhibitory concentrations were similar. In particular, HM-242 killed various Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, both efficiently and rapidly. HM-242 also showed potent virucidal activity against enveloped viruses such as influenza virus and herpes simplex virus. These characteristics suggest that HM-242 may well be useful as an antiseptic.

机译：N（4）-辛基-6,6-二甲基-N（2）-（4-甲基苄基）-1,6-二氢-1,3,5-三嗪-2,4-二胺（HM的抗菌活性-242），一种新型合成化合物，与葡萄糖酸氯己定（CHG）进行了比较。 HM-242在体外比CHG更有效。然而，其最小抑菌浓度却相似。尤其是，HM-242可以快速有效地杀死各种革兰氏阳性细菌，包括耐甲氧西林的金黄色葡萄球菌和耐万古霉素的粪肠球菌。 HM-242还显示出对包膜病毒（例如流感病毒和单纯疱疹病毒）的有效杀病毒活性。这些特征表明HM-242很可能用作防腐剂。

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《The Journal of Antibiotics: An International Journal》 |2009年第9期|共5页
作者
Okunishi J; Nishihara Y; Maeda S; Ikeda M;
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In vitro evaluation of the antimicrobial activity of HM-242, a novel antiseptic compound.

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