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首页> 外文期刊>The Journal of Antibiotics: An International Journal >In vitro activity of two old antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus.
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In vitro activity of two old antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus.

机译：两种旧抗生素对耐甲氧西林金黄色葡萄球菌临床分离株的体外活性。

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摘要

The objective of this paper was to investigate the in vitro effects of fusidic acid combined with fosfomycin against methicillin-resistant Staphylococcus aureus (MRSA). In all, 196 MRSA strains isolated from three clinical specimens of human infections from hospitals in China were used in this study. The checkerboard method was used to determine whether combinations act synergistically against these strains. The susceptibility results for fusidic acid and fosfomycin were interpreted according to the guidelines of the Clinical and Laboratory Standards Institute. The combination of fusidic acid and fosfomycin demonstrated the following interactions: 87.76% (172/196) synergism, 12.24% (24/196) indifference and no antagonism was seen (minimum and maximum fractional inhibitory concentration index 0.14 and 0.75, respectively). Thus, combinations of fusidic acid and fosfomycin show synergism for most of the MRSA isolates tested in this study, and may be a future therapeutic alternative for infections caused by MRSA.
机译：本文的目的是研究夫西地酸联合磷霉素对耐甲氧西林金黄色葡萄球菌（MRSA）的体外作用。总共从中国医院的三份人类感染临床标本中分离出196株MRSA菌株。棋盘格方法用于确定组合是否对这些菌株具有协同作用。根据临床和实验室标准协会的指南解释了夫西地酸和磷霉素的药敏结果。夫西地酸和磷霉素的组合显示出以下相互作用：87.76％（172/196）协同作用，12.24％（24/196）的冷漠且未见拮抗作用（最小和最大分数抑制浓度指数分别为0.14和0.75）。因此，夫西地酸和磷霉素的组合对本研究中测试的大多数MRSA分离物显示出协同作用，并且可能是MRSA引起的感染的未来治疗选择。

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