TMC -256A1 and C1,new inhibitors of IL-4 signal transduction produced by aspergillus niger var niger TC 1629

Masaaki Sakurai; Jun Kohno; Kouzou Yamamoto; Tetsuo Ohnuki

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TMC -256A1 and C1,new inhibitors of IL-4 signal transduction produced by aspergillus niger var niger TC 1629

机译：TMC -256A1和C1，黑曲霉var Niger TC 1629产生的新型IL-4信号转导抑制剂

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New inhibitors of IL-4 signal ransduction,designated as TMC-256A1 and C1,were discovered together with TMC-256B1,a previously known dihydronaphthopyrone,from the fermentation broth of Aspergillus niger var niger TC 1629 BY USING AN il-4 driven reporter gene assay.Based on spectroscopic analyses,TMC-256A1 and C1 were found to be new members of the naphthopyrone antibiotics.TMC-256A1,B1 and C1 inhibited theIL-4 driven luciferase activity with IC_(50) values of 25 muM,30 muM and 1.7 muM,respectivley in this assay system.Furthermore,these compounds inhibited the expressio of germline Cepsilon mRNA with IC-(50) values of 6.6 muM,34 muM and 0.31 muM,respectivley.

机译：通过使用il-4驱动的报告基因，从黑曲霉黑变种TC 1629的发酵液中发现了新的IL-4信号转导抑制剂，命名为TMC-256A1和C1，以及先前已知的二氢萘并吡喃酮TMC-256B1。根据光谱分析，TMC-256A1和C1被认为是萘并吡喃酮抗生素的新成员.TMC-256A1，B1和C1抑制了IL-4驱动的荧光素酶活性，IC_（50）值为25μM，30μM和在该测定系统中，该化合物的抑制作用为1.7μM。此外，这些化合物抑制种Cepsilon mRNA的表达，其IC-（50）值分别为6.6μM，34μM和0.31μM。

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《The Journal of Antibiotics: An International Journal》 |2002年第8期|共8页
作者
Masaaki Sakurai; Jun Kohno; Kouzou Yamamoto; Tetsuo Ohnuki;
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正文语种 eng
中图分类药学;药品;
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1. TMC -256A1 and C1,new inhibitors of IL-4 signal transduction produced by aspergillus niger var niger TC 1629 [J] . Masaaki Sakurai, Jun Kohno, Kouzou Yamamoto, The Journal of Antibiotics: An International Journal . 2002,第8期

机译：TMC -256A1和C1，黑曲霉var Niger TC 1629产生的新型IL-4信号转导抑制剂
2. Implica??es do fungo Aspergillus niger var. niger sobre o crescimento de isolados de Aspergillus da se??o Circumdati e produ??o de Ocratoxina a [J] . Juliane Rezende Mercer, Luís Roberto Batista, Sara Maria Chalfoun De Souza Ciência e Agrotecnologia . 2003,第5期

机译：真菌黑曲霉的影响。黑麦对Circumdati切片中曲霉菌的生长和Ocratoxin a产量的影响
3. Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88. [J] . Andersen MR, Salazar MP, Schaap PJ, Genome research . 2011,第6期

机译：产生柠檬酸的黑曲霉ATCC 1015与产生酶的CBS 513.88的比较基因组学。
4. Aspergillus niger ATCC 16404 Producing Pectinase Couple To Polysulfone/Pluronic Membrane Ultrafiltration For Momordica Charantia Juice Clarification [C] . Nurul Atikah Mohd Rais, Norazlina ldris, Shareena Fairuz Abdul Manaf International Conference Global Sustainability and Chemical Engineering . 2015

机译：Aspergillus尼日尔ATCC 16404生产果胶酶夫妇，以苦瓜的聚砜/ Pluronic膜超滤液体澄清
5. Extraction and Partial Purification of α-amylase Produced by Aspergillus niger Cultured on Banana Peel (Musa acumunata) [D] . Magaji, Rabiat Abiola. 2018

机译：香蕉果皮（Musa Acumunata）培养的曲霉患者α-淀粉酶的提取及部分纯化
6. Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88 [O] . Mikael R. Andersen, Margarita P. Salazar, Peter J. Schaap, 2011

机译：产生柠檬酸的黑曲霉ATCC 1015与产生酶的CBS 513.88的比较基因组学
7. Implicações do fungo Aspergillus niger var. niger sobre o crescimento de isolados de Aspergillus da seção Circumdati e produção de Ocratoxina a Implications of Aspergillus niger var. niger's mold, fungi upon growing Aspergillus's isolate of section Circumdati and Ochratoxin a [O] . Patrícia Prado Nasser, Sara Maria Chalfoun de Souza, Luís Roberto Batista, 2003

机译：真菌黑曲霉的影响。黑曲霉对Circumdati切片中曲霉菌的生长和奥曲霉毒素的产生-黑曲霉的影响。尼日尔霉菌，切段曲霉菌和O曲霉毒素a的分离曲霉菌生长后的真菌

TMC -256A1 and C1,new inhibitors of IL-4 signal transduction produced by aspergillus niger var niger TC 1629

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