New antibiotics miyakamides produced by a fungus

Kazuro Shiomi; Kenji Hatae; Yuichi Yamaguchi; Rokuro Masuma; Hiroshi Tomoda; Susumu Kobayashi; Satoshi Omura

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New antibiotics miyakamides produced by a fungus

机译：真菌产生的新抗生素宫般酰胺

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New antibiotics, miyakamides A_1, A_2, B_1, and B_2, were isolated from the cultured broth of Aspergillus flavus Link var. columnaris FKI-0739 together with known compounds, parasiticolide A, hydroxyaspergillic acid, and kojic acid. The structure of miyakamide A_1 is N-acetyl-L-phenylalanyl-N-methyl-L-phenylalanyl-(alphaZ)-alpha, beta-didehydrotryptamine, and miyakamide A_2 is E isomer of A_1 at didehydrotryptamine. The structure of miyakamide B_1 is N-acetyl-L-tyrosyl-N-methyl-L-phenylalanyl-(alphaZ)-alpha,beta-didehydrotryptamine, and B_2 is E isomer of B_1. Both miyakamides A_1 and B_1 existed as equilibrium isomers in solvents, and this isomerism was associated with cis-trans rotation of the amide bond between two amino acids. Conformational isomerism between two amino acids of miyakamides A_2 and B_2 is cis-form. Miyakamides showed growth inhibitory activity against brine shrimp, Artemia salina.

机译：从黄曲霉Link var的培养液中分离出新的抗生素，宫缩酰胺A_1，A_2，B_1和B_2。 columnaris FKI-0739以及已知的化合物，抗寄生虫药A，羟磷灰石酸和曲酸。宫酰胺A_1的结构是N-乙酰基-L-苯丙氨酰基-N-甲基-L-苯丙氨酰基-（αZ）-α，β-二脱氢色胺，而宫酰胺A_2是A_1在二脱氢色胺上的E异构体。宫古酰胺B_1的结构为N-乙酰基-L-酪氨酰基-N-甲基-L-苯丙氨酰基-（αZ）-α，β-二脱氢色胺，B_2为B_1的E异构体。宫古酰胺A_1和B_1均以平衡异构体的形式存在于溶剂中，并且这种异构现象与两个氨基酸之间酰胺键的顺反旋转有关。宫酰胺A_2和B_2的两个氨基酸之间的构象异构是顺式。 Miyakamides对盐水虾Artemia salina具有生长抑制活性。

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《The Journal of Antibiotics: An International Journal》 |2002年第11期|共10页
作者
Kazuro Shiomi; Kenji Hatae; Yuichi Yamaguchi; Rokuro Masuma; Hiroshi Tomoda; Susumu Kobayashi; Satoshi Omura;
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正文语种 eng
中图分类药学;药品;
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1. New antibiotics miyakamides produced by a fungus [J] . Kazuro Shiomi, Kenji Hatae, Yuichi Yamaguchi, The Journal of Antibiotics: An International Journal . 2002,第11期

机译：真菌产生的新抗生素宫般酰胺
2. A new antibiotic produced by the cyanobacterium-symbiotic fungus Simplicillium lanosoniveum [J] . Qinglin Dong, Rongzhen Dong, Xiangying Xing Yukuan Li Natural product research . 2018,第10a12期

机译：由蓝杆菌 - 共生真菌Simplicilliumlanosoniveum产生的新抗生素
3. Muscodor tigerii sp. nov.-Volatile antibiotic producing endophytic fungus from the Northeastern Himalayas [J] . Sanjai Saxena, Vineet Meshram, Neha Kapoor Annals of microbiology . 2015,第1期

机译：Muscodor tigerii sp。十一月-东北喜马拉雅山产挥发性抗生素的内生真菌
4. Biotic Elicitor, Staphylococcus aureus, Stimulated Antibiotics Production from a Local Fungus of Tropical Peat Swamp Soil, Penicillium sp. LBKURCC34 [C] . Y. Nurulita, Yuharmen, A. Fitri, International Conference of the Indonesian Chemical Society . 2020

机译：生物诱导剂，金黄色葡萄球菌，刺激抗生素生产从热带泥炭沼泽土壤的局部真菌，Penicillium sp。 lbkurcc34
5. Attine-fungus mutualism: Prophylactic behavior, parasites and use of antibiotics. [D] . Fernandez-Marin, Hermogenes. 2006

机译：Attine-真菌共生：预防行为，寄生虫和抗生素的使用。
6. Two New Antibiotic Pyridones Produced by a Marine Fungus Trichoderma sp. Strain MF106 [O] . Bin Wu, Vanessa Oesker, Jutta Wiese, 2014

机译：海洋真菌Trichoderma sp。生产的两种新型抗生素吡啶酮。菌株MF106
7. Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 [O] . Bin Wu, Vanessa Oesker, Jutta Wiese, 2014

机译：由海洋真菌（Trichoderma sp。）产生的两种新的抗生素吡啶酮。应变mF106

New antibiotics miyakamides produced by a fungus

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