Kynapcin-13 and-28, new benzofuran prolyl endopeptidase inhibitors from polyozellus multiplex

Sang-In Kim; In-Hye Park; Kyung-Sik Song

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Kynapcin-13 and-28, new benzofuran prolyl endopeptidase inhibitors from polyozellus multiplex

机译：Kynapcin-13和-28，来自多虫复合体的新型苯并呋喃脯氨酰内肽酶抑制剂

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Two new benzofurans, 5,6-dihydroxybenzofuran-2,3-dicarboxylic acid dimethyl ester (kynapcin-13) and 5,6, 5',6'-tetrahydroxy[3,3']bibenzofuranyl-2,2'-dicarboxylic acid 2'-methyl ester (kynapcin-28) were isolated from Polyozellus multiplex, and shown to non-competitively inhibit prolyl endopeptidase (PEP), with the IC_(50) values of 76.80 and 0.98 muM, respectively. Kynapcin-13 and -28 were less inhibitory to other serine proteases such as chymotrypsin, trypsin, and elastase.

机译：两种新的苯并呋喃，5,6-二羟基苯并呋喃-2,3-二羧酸二甲酯（Kynapcin-13）和5,6，5'，6'-四羟基[3,3'] bibenzofuranyl-2,2'-二羧酸从Polyozellus multiplex中分离出2'-甲酯（kynapcin-28），并显示出非竞争性抑制脯氨酰内肽酶（PEP）的作用，IC_（50）值分别为76.80和0.98μM。 Kynapcin-13和-28对其他丝氨酸蛋白酶（如胰凝乳蛋白酶，胰蛋白酶和弹性蛋白酶）的抑制作用较小。

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《The Journal of Antibiotics: An International Journal》 |2002年第7期|共6页
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Sang-In Kim; In-Hye Park; Kyung-Sik Song;
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正文语种 eng
中图分类药学;药品;
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1. Kynapcin-13 and-28, new benzofuran prolyl endopeptidase inhibitors from polyozellus multiplex [J] . Sang-In Kim, In-Hye Park, Kyung-Sik Song The Journal of Antibiotics: An International Journal . 2002,第7期

机译：Kynapcin-13和-28，来自多虫复合体的新型苯并呋喃脯氨酰内肽酶抑制剂
2. A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex [J] . Song KS, Raskin I Journal of natural products . 2002,第1期

机译：Polyozellus multiflex的脯氨酰内肽酶抑制苯并呋喃二聚体
3. Kynapcin-12, a New p-Terphenyl Derivative from Polyozellus multiples, Inhibits Prolyl Endopeptidase [J] . LEE HYUN-JIN The Journal of Antibiotics: An International Journal . 2000,第7期

机译：Kynapcin-12，一种来自Polyozellus倍数的新型对-三联苯衍生物，可抑制脯氨酰内肽酶
4. Identification of an unusual cleavage site for prolyl endopeptidase:investigation of the breakdown of the octadecaneuropeptide ODN [C] . Jerome Leprince, David Cosquer, Gaelle Bellemere International Peptide Symposium;European Peptide Symposium . 2005

机译：鉴定脯氨酰内肽酶的不寻常的切割位点：调查十八烷酮肽的崩溃ODN
5. Expression of glutenases in wheat (Triticum aestivum L.) endosperm and increase in the thermostability of prolyl endopeptidase from Flavobacterium meningosepticum as an alternative therapy for celiac patients. [D] . Osorio, Claudia E. 2013

机译：谷氨酸酶在小麦（Triticum aestivum L.）胚乳中的表达和脑膜炎黄杆菌中脯氨酰内肽酶的热稳定性增加，可作为乳糜泻患者的替代疗法。
6. In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice [O] . Bertrand Perroud, Rudy J Alvarado, Glenda M Espinal, 2009

机译：脯氨酰内肽酶缺乏症小鼠垂体中3种形式的α黑素细胞刺激激素的体内多重定量分析
7. Poststatin, a New Inhibitor of Prolyl Endopeptidase. VI. Endopeptidase Inhibitory Activity of Poststatin Analogues Containing Pyrrolidine Ring. [O] . MAKOTO TSUDA, YASUHIKO MURAOKA, TETSUYA SOMENO, 1996

机译：Poststatin，一种新的脯氨酰内肽酶的抑制剂。 VI。含有吡咯烷环的后顿素类似物的内肽酶抑制活性。

Kynapcin-13 and-28, new benzofuran prolyl endopeptidase inhibitors from polyozellus multiplex

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