Nocathiacins, new thiazolyl peptide antibiotics from nocardia sp. I. Taxonomy, fermentation and biological activities

Wenying Li; John E.Leet; Helen A.Ax; Donald R.Gustavson; Daniel M.Brown; Laura Turner; Kimberly Brown; Junius Clark; Hyekyung Yang; Joan Fung-Tomc; Kin S.Lam

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Nocathiacins, new thiazolyl peptide antibiotics from nocardia sp. I. Taxonomy, fermentation and biological activities

机译：Nocathiacins，nocardia sp。的新型噻唑基肽抗生素。一，分类学，发酵和生物活动

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Thiazolyl peptide antibiotics, nocathiacin I, II and III, were identified in a culture of Nocardia sp. WW-12651 (ATCC 202099). They exhibit potent in vitro activity (ng/ml) against a wide spectrum of Gram-positive bacteria, including multiple-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), multi-drug resistant Enterococcus faecium (MREF) and fully penicillin-resistant Streptococcus pneumoniae (PRSP), and demonstrate excellent in vivo efficacy in a systemic Staphylococcus aureus infection mice model.

机译：在诺卡氏菌（Nocardia sp。）的培养物中鉴定出噻唑基肽抗生素，诺卡他霉素I，II和III。 WW-12651（ATCC 202099）。它们对多种革兰氏阳性细菌表现出有效的体外活性（ng / ml），包括对多种药物具有耐药性的病原体，如耐甲氧西林的金黄色葡萄球菌（MRSA），耐多种药物的粪肠球菌（MREF）和完全青霉素耐药性肺炎链球菌（PRSP），并在系统性金黄色葡萄球菌感染小鼠模型中显示出优异的体内功效。

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《The Journal of Antibiotics: An International Journal》 |2003年第3期|共6页
作者
Wenying Li; John E.Leet; Helen A.Ax; Donald R.Gustavson; Daniel M.Brown; Laura Turner; Kimberly Brown; Junius Clark; Hyekyung Yang; Joan Fung-Tomc; Kin S.Lam;
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正文语种 eng
中图分类药学;药品;
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1. Nocathiacins, new thiazolyl peptide antibiotics from nocardia sp. I. Taxonomy, fermentation and biological activities [J] . Wenying Li, John E.Leet, Helen A.Ax, The Journal of Antibiotics: An International Journal . 2003,第3期

机译：Nocathiacins，nocardia sp。的新型噻唑基肽抗生素。一，分类学，发酵和生物活动
2. Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. I. Taxonomy, fermentation, isolation and biological activities. [J] . Hoshino Y, Mukai A, Yazawa K, The Journal of Antibiotics: An International Journal . 2004,第12期

机译：Transvalencin A，一种噻唑烷锌复合抗生素，由临床上的诺华氏诺卡氏菌分离得到。 I.分类学，发酵，分离和生物活动。
3. Nocathiacin I analogues: synthesis, in vitro and in vivo biological activity of novel semi-synthetic thiazolyl peptide antibiotics. [J] . Naidu BN, Sorenson ME, Zhang Y, Bioorganic and Medicinal Chemistry Letters . 2004,第22期

机译：Nocathiacin I类似物：新型半合成噻唑基肽抗生素的合成，体外和体内生物学活性。
4. Fermentation of soybean (Glycine max (I.) merr) using mix inocula of Rhizopus sp. and Sacharomycescereviceae for alternative source of folic acid [C] . Y Maryati, A Susilowati, H Melanie International Conference on Science and Innovated Engineering . 2019

机译：使用Rhizopus sp的混合接种糖的大豆（甘氨酸Max（I.）Merr）发酵。和Sacharomycesceerviceae用于叶酸的替代来源
5. Part I. Application of 2-hydroxymethylacrylic acid, a product of Baylis-Hillman reaction, for the synthesis of novel N-backbone-to-side-chain cyclic peptide analogs: Strategies and side reactions. Part II. Synthesis and biological activities of chimeric bioactive peptides featuring amino acids coupled to 4-anilino-n-phenethyl-piperidine. [D] . Petrov, Ravil Rashitovich. 2007

机译：第一部分。Baylis-Hillman反应产物2-羟甲基丙烯酸在合成新型N骨架至侧链环状肽类似物中的应用：策略和副反应。第二部分具有与4-苯胺基-n-苯乙基-哌啶偶联的氨基酸的嵌合生物活性肽的合成和生物活性。
6. Correction: Singh, M.P., et al. Cytoskyrins and Cytosporones Produced by Cytospora sp. CR200: Taxonomy, Fermentation and Biological Activities [O] . Maya P. Singh, Jeffrey E. Janso, Sean F. Brady 2018

机译：校正：Singh，M.P.等。 Cytospora sp。生产的Cytoskyrins和Cytosporones。 CR200：分类学，发酵和生物活动
7. Arylomycins A and B, New Biaryl-bridged Lipopeptide Antibiotics Produced by Streptomyces sp. Tue 6075. I. Taxonomy, Fermentation, Isolation and Biological Activities. [O] . JUDITH SCHIMANA, KLAUS GEBHARDT, ALEXANDRA HÖLTZEL, 2002

机译：芳基霉素A和B，通过链霉菌SP产生的新的胆汁桥脂肽抗生素。 Tue 6075. I.分类，发酵，分离和生物活性。
8. Regulation of a Post-Translational Peptide Acetyltransferase: Strategies forSelectively Modifying the Biological Activity of Neural and Endocrine Peptides [R] . Millington, W. R. 1991

机译：调节翻译后肽乙酰转移酶：选择性修改神经和内分泌肽的生物活性的策略

Nocathiacins, new thiazolyl peptide antibiotics from nocardia sp. I. Taxonomy, fermentation and biological activities

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