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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Asperaldin, a New Aldose Reductase Inhibitor from Aspergillus niger CFR-1046: I. Fermentation, Isolation and Characterization
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Asperaldin, a New Aldose Reductase Inhibitor from Aspergillus niger CFR-1046: I. Fermentation, Isolation and Characterization

机译：黑曲霉CFR-1046的新型醛糖还原酶抑制剂阿斯帕拉丁：I.发酵，分离和表征

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摘要

Aldose reductase (EC 1.1.1.21) catalyzes the conversion of glucose to sorbitol and promotes the accumulation of sorbitol in various tissues under the condition of hyperglycemia such as diabetes mellitus. The accumulated intracellular sorbitol causes development of diabetic complications such as cataracts, neuropathy, retinopathy and nephropathy~1). Inhibitors of aldose reductase have been shown to reverse these biochemical changes and have been proven effective in delaying and even preventing several diabetic pathologies. Thus, aldose reductase has become an attractive pharmacological target for the treatment of diabetic complications. It has been reported that inhibitors of aldose reductase reduce the tissue sorbitol content in diabetic animals and are useful as thermapeutic agents for ciabetic complications~2).
机译：醛糖还原酶（EC 1.1.1.21）催化葡萄糖转化为山梨糖醇，并促进高糖血症（如糖尿病）下各种组织中山梨糖醇的积累。累积的细胞内山梨醇会导致糖尿病并发症的发展，例如白内障，神经病，视网膜病变和肾病〜1）。醛糖还原酶的抑制剂已被证明可以逆转这些生化变化，并已被证明可以有效地延缓甚至预防几种糖尿病的发生。因此，醛糖还原酶已成为治疗糖尿病并发症的有吸引力的药理靶标。据报道，醛糖还原酶抑制剂可降低糖尿病动物的组织中山梨糖醇含量，可用作治疗糖尿病并发症的热疗剂〜2）。

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