Isolation and Characterization of Two New Antifungal Antibiotics from a Basidiomycete

Min Chu; Ronald Mierzwa; Ling Xu; Ling He; Erik Langsdorf; Martha Beyazova; Joseph Terracciano; Mahesh Patel; Tze-Ming Chan; Vincent Gullo

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Isolation and Characterization of Two New Antifungal Antibiotics from a Basidiomycete

机译：担子菌中两种新型抗真菌抗生素的分离与鉴定

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Two novel antibiotics, Sch 48129 (1) and Sch 484130 (2), were isolated from the fermentation broth of a fungal culture, which was identified as a Basidiomycete. The new antibiotics were obtained by ethyl acetate extraction followed by reversed phase HPLC purification. Structure elucdation of 1 and 2 was accomplished by spectrorscopic data analyses. Derivatizations of the major component 1 were performed in order to provide definitive structural information. BGoth components were identified as glycolipids and displayed antifungal activity against Saccharomyces and Aspergillus strains.

机译：从真菌培养物的发酵液中分离了两种新型抗生素Sch 48129（1）和Sch 484130（2），该菌被鉴定为担子菌。通过乙酸乙酯萃取，然后反相HPLC纯化获得新的抗生素。 1和2的结构解析是通过光谱数据分析完成的。为了提供确定的结构信息，对主要部件1进行了衍生化处理。 BGoth成分被鉴定为糖脂，并显示出对酿酒酵母和曲霉菌株的抗真菌活性。

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《The Journal of Antibiotics: An International Journal》 |2003年第1期|共7页
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Min Chu; Ronald Mierzwa; Ling Xu; Ling He; Erik Langsdorf; Martha Beyazova; Joseph Terracciano; Mahesh Patel; Tze-Ming Chan; Vincent Gullo;
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正文语种 eng
中图分类药学;药品;
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1. Isolation and Characterization of Two New Antifungal Antibiotics from a Basidiomycete [J] . Min Chu, Ronald Mierzwa, Ling Xu, The Journal of Antibiotics: An International Journal . 2003,第1期

机译：担子菌中两种新型抗真菌抗生素的分离与鉴定
2. Molecular characterization and in vitro antifungal susceptibility profile of schizophyllum commune, an emerging basidiomycete in bronchopulmonary mycoses [J] . ChowdharyA., KathuriaS., SinghP.K., Antimicrobial agents and chemotherapy. . 2013,第6期

机译：支气管霉菌中新兴的担子菌Schizophyllum commune的分子表征和体外抗真菌药性
3. Isolation and Characterization of a Ubiquitin-Like Ribonuclease from the Cultured Deep Root Mushroom, Oudemansiella radicata (Higher Basidiomycetes) [J] . Liu Qin, Chen Hao, Wang Hexiang, International Journal of Medicinal Mushrooms . 2015,第11期

机译：从培养的深根蘑菇，Oudemansiella radicata（较高的担子菌）泛素样核糖核酸酶的分离和表征。
4. Isolation and Characterization of an Impurity Obtained During the Synthesis of the Antibiotic Drug Sparfloxacin [C] . Nirmala Munigela, Moses Babu J., Anjaneyulu Yerramilli, Scientia pharmaceutica . 2009

机译：抗生素Sparfloxacin合成过程中获得的杂质的分离和表征
5. Cloning and characterization of the peptide synthetase gene cluster involved in the nonribosomal biosynthesis of fusaricidin-type antifungal antibiotics in Paenibacillus polymyxa PKB1. [D] . Li, Jingru. 2007

机译：多粘芽孢杆菌PKB1中镰刀菌素类抗真菌抗生素的非核糖体生物合成中涉及的肽合成酶基因簇的克隆和鉴定。
6. Molecular Characterization and In Vitro Antifungal Susceptibility Profile of Schizophyllum commune an Emerging Basidiomycete in Bronchopulmonary Mycoses [O] . Anuradha Chowdhary, Shallu Kathuria, Pradeep Kumar Singh, 2013

机译：Schizophyllum comunune支气管肺结核中新兴的担子菌的分子表征和体外抗真菌药性概况。
7. Isolation and characterization of phosmidosine a new antifungal nucleotide antibiotic. [O] . MASAKAZU URAMOTO, CHANG-JIN KIM, KAZUO SHIN-YA, 1991

机译：Phosmidosine一种新型抗真菌核苷酸抗生素的分离与表征。

Isolation and Characterization of Two New Antifungal Antibiotics from a Basidiomycete

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