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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Aspergillus mulundensis sp. nov., a new species for the fungus producing the antifungal echinocandin lipopeptides, mulundocandins
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Aspergillus mulundensis sp. nov., a new species for the fungus producing the antifungal echinocandin lipopeptides, mulundocandins

机译:mulundensis sp。十一月,生产抗真菌棘皮棘菌素脂肽,多菌素的真菌新物种

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摘要

The invalidly published name Aspergillus sydowii var. mulundensis was proposed for a strain of Aspergillus that produced new echinocandin metabolites designated as the mulundocadins. Reinvestigation of this strain (Y-30462 = DSMZ 5745) using phylogenetic, morphological, and metabolic data indicated that it is a distinct and novel species of Aspergillus sect. Nidulantes. The taxonomic novelty, Aspergillus mulundensis, is introduced for this historically important echinocandin-producing strain. The closely related A. nidulans FGSC A4 has one of the most extensively characterized secondary metabolomes of any filamentous fungus. Comparison of the full-genome sequences of DSMZ 5745 and FGSC A4 indicated that the two strains share 33 secondary metabolite biosynthetic gene clusters. These shared gene clusters represent similar to 45% of the total secondary metabolome of each strain, thus indicating a high level intraspecific divergence in terms of secondary metabolism.
机译:无效发布的名称Aspergillus sydowii var。提出了将mulundensis用于产生新的棘皮菌素代谢产物称为mulundocadins的曲霉菌株。使用系统发育,形态学和代谢数据对该菌株(Y-30462 = DSMZ 5745)进行的重新研究表明,它是曲霉菌属的一个独特而新颖的物种。 Nidulantes。为这种具有历史意义的棘皮菌素高产菌株引入了分类学上的新奇种,即mulundensis mulundensis。紧密相关的构巢曲霉FGSC A4具有丝状真菌中最广泛表征的次级代谢组之一。 DSMZ 5745和FGSCA4的全基因组序列比较表明,这两个菌株共有33个次级代谢产物生物合成基因簇。这些共有的基因簇代表每个菌株总次级代谢组的45%,因此在次级代谢方面显示出高水平的种内差异。

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