AS1387392, a novel immunosuppressive cyclic tetrapeptide compound with inhibitory activity against mammalian histone deacetylase.

Sasamura S; Sakamoto K; Takagaki S; Yamada T; Takase S; Mori H; Fujii T; Hino M; Hashimoto M

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AS1387392, a novel immunosuppressive cyclic tetrapeptide compound with inhibitory activity against mammalian histone deacetylase.

机译：AS1387392，一种对哺乳动物组蛋白脱乙酰基酶具有抑制活性的新型免疫抑制性环状四肽化合物。

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The novel immunosuppressant AS1387392 has been isolated from Acremonium sp. No. 27082. This compound showed a strong inhibitory effect against mammalian histone deacetylase and T-cell proliferation. Further, AS1387392 showed a good oral absorption, and its plasma concentration was higher than that of FR235222, an analog of AS1387392 that inhibited histone deacetylase previously reported. Given these findings, AS1387392 may represent an important new lead in developing immunosuppressant.

机译：新的免疫抑制剂AS1387392已从顶孢属（Acremonium sp。）分离。 No.27082。该化合物显示出对哺乳动物组蛋白脱乙酰基酶和T细胞增殖的强抑制作用。此外，AS1387392显示出良好的口服吸收，并且其血浆浓度高于FR235222，后者是先前报道的抑制组蛋白脱乙酰基酶的AS1387392类似物。鉴于这些发现，AS1387392可能代表了开发免疫抑制剂的重要新线索。

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《The Journal of Antibiotics: An International Journal》 |2010年第11期|共4页
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Sasamura S; Sakamoto K; Takagaki S; Yamada T; Takase S; Mori H; Fujii T; Hino M; Hashimoto M;
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1. AS1387392, a novel immunosuppressive cyclic tetrapeptide compound with inhibitory activity against mammalian histone deacetylase. [J] . Sasamura S, Sakamoto K, Takagaki S, The Journal of Antibiotics: An International Journal . 2010,第11期

机译：AS1387392，一种对哺乳动物组蛋白脱乙酰基酶具有抑制活性的新型免疫抑制性环状四肽化合物。
2. Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that inhibits mammalian histone deacetylases [J] . Xie WQ, Zou B, Pei DQ, Organic letters . 2005,第13期

机译：环状四肽FR235222的全合成，一种抑制哺乳动物组蛋白脱乙酰基酶的有效免疫抑制剂
3. Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that inhibits mammalian histone deacetylases [J] . Xie WQ, Zou B, Pei DQ, Organic letters . 2005,第13期

机译：环状四肽FR235222的全合成，一种抑制哺乳动物组蛋白脱乙酰基酶的有效免疫抑制剂
4. Cyclic Tetrapeptides containing N-Isopropylglycine as Histone Deacetylase Inhibitors [C] . Satoko Matsuo, Tamaki Kato, Norikazu Nishino Japanese peptide symposium . 2011

机译：含有N-异丙基甘氨酸的环状四肽作为组蛋白脱乙酰酶抑制剂
5. I. Comparison of translesion bypass of guanine-N2 monoadducts of mitomycin C and guanine -N7 monoadducts of 2,7-diaminomitosene by T7 exo-, Klenow exo-, eta and Klenow exo+ DNA polymerases. II. Structure-based design, synthesis, structure-conformation and structure -activity relationships studies of D-Phe-Pro-D-Arg-P1'-CONH2 tetrapeptides with inhibitory activity for thrombin. [D] . Clement, Cristina C. 2006

机译：I.通过T7 exo-，Klenow exo-，eta和Klenow exo + DNA聚合酶比较丝裂霉素C的鸟嘌呤-N2单加合物和2,7-二氨基光油的鸟嘌呤-N7单加合物的跨病变旁路。二。具有凝血酶抑制活性的D-Phe-Pro-D-Arg-P1'-CONH2四肽的基于结构的设计，合成，结构构象和结构-活性关系研究。
6. Synthesis of 2-aminosuberic acid derivatives as components of some histone deacetylase inhibiting cyclic tetrapeptides [O] . Shital Kumar Chattopadhyay, Suman Sil, Jyoti Prasad Mukherjee 2017

机译：某些组蛋白脱乙酰基酶抑制环四肽成分的2-氨基磺酸衍生物的合成
7. AS1387392, a novel immunosuppressive cyclic tetrapeptide compound with inhibitory activity against mammalian histone deacetylase [O] . Satoshi Sasamura, Kazutoshi Sakamoto, Shoji Takagaki, 2010

机译：AS1387392，一种新型免疫抑制环状四肽化合物，具有抑制哺乳动物组蛋白脱乙酰酶的抑制活性

AS1387392, a novel immunosuppressive cyclic tetrapeptide compound with inhibitory activity against mammalian histone deacetylase.

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