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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Hutchinson's legacy: keeping on polyketide biosynthesis.
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Hutchinson's legacy: keeping on polyketide biosynthesis.

机译:哈钦森的遗产:保持聚酮化合物的生物合成。

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摘要

Professor Charles Richard Hutchinson (Hutch) dedicated his research to the study of polyketide compounds, in particular, those produced by actinomycetes. Hutch principally centered his efforts to study the biosynthesis of bioactive compounds, antibiotic and antitumor drugs, and to develop new derivatives with improved therapeutic properties. After dedicating 40 years to the study of polyketides, Hutch leaves us, as legacy, the knowledge that he and his collaborators have accumulated and shared with the scientific community. The best tribute we can offer to him is keeping on the study of polyketides and other bioactive compounds, in an effort to generate more safer and useful drugs. In this review, the work on the polyketides, borrelidin, steffimycin and streptolydigin, performed at the laboratory of Professors Salas and Mendez at University of Oviedo (Spain) during the last 10 years, is summarized.
机译:查尔斯·理查德·哈钦森(Charles Richard Hutchinson)教授(Hutch)致力于研究聚酮化合物,特别是放线菌产生的化合物。 Hutch主要致力于研究生物活性化合物,抗生素和抗肿瘤药物的生物合成,并开发具有改善治疗特性的新衍生物。在致力于聚酮化合物研究40年之后,Hutch留下了他和他的合作者积累并与科学界共享的知识,作为遗产。我们可以向他致敬的是继续研究聚酮化合物和其他生物活性化合物,以期生产出更安全和有用的药物。在这篇综述中,总结了过去10年间在西班牙奥维耶多大学Salas和Mendez教授的实验室中进行的关于聚酮化合物,硼瑞丁,steffimycin和streptolydigin的研究。

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