3′-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory diaryl ethers from a Steganospora species

SchreiberD.; JungM.; SandjoL.P.; LiermannJ.C.; OpatzT.; ErkelG.

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3′-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory diaryl ethers from a Steganospora species

机译：3'-去甲基二氢麦芽毒素和二氢麦芽毒素，两种来自隐孢子虫的抗炎性二芳基醚

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CXCL10 (IP-10) is a highly inducible chemoattractant, which contributes to the recruitment of inflammatory cells such as macrophages and T-lymphocytes and thereby has important roles in chronic inflammatory conditions. In a search for new inhibitors of CXCL10 expression in MonoMac6 (MM6) cells, the new diaryl ether 3′-demethyldihydromaldoxin (1) along with the known compound dihydromaldoxin (2), were isolated from fermentations of a Steganospora species. The structures of the compounds were elucidated by a combination of one-and two-dimensional NMR spectroscopy and mass spectrometry. Compounds (1) and (2) inhibited lipopolysaccharide (LPS)/interferon-γ (IFN-γ)-induced CXCL10 promoter activity in transiently transfected MM6 cells in a dose-dependent manner with IC 50 values of 39-41 M and also reduced LPS/IFN-γ-induced CXCL10 protein synthesis and excretion.

机译：CXCL10（IP-10）是一种高度诱导性的化学引诱剂，可促进炎症细胞（如巨噬细胞和T淋巴细胞）的募集，因此在慢性炎症条件下具有重要作用。为了寻找在MonoMac6（MM6）细胞中表达CXCL10的新抑制剂，新的二芳基醚3'-去甲基二氢麦芽毒素（1）与已知的化合物二氢麦芽毒素（2）均已从隐孢子虫的发酵中分离出来。通过一维和二维NMR光谱法和质谱法的结合来阐明化合物的结构。化合物（1）和（2）以剂量依赖性方式抑制瞬时转染的MM6细胞中脂多糖（LPS）/干扰素-γ（IFN-γ）诱导的CXCL10启动子活性，IC 50值为39-41 M，并且也降低LPS /IFN-γ诱导的CXCL10蛋白合成和排泄。

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《The Journal of Antibiotics: An International Journal》 |2012年第9期|共5页
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SchreiberD.; JungM.; SandjoL.P.; LiermannJ.C.; OpatzT.; ErkelG.;
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正文语种 eng
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1. 3′-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory diaryl ethers from a Steganospora species [J] . SchreiberD., JungM., SandjoL.P., The Journal of Antibiotics: An International Journal . 2012,第9期

机译：3'-去甲基二氢麦芽毒素和二氢麦芽毒素，两种来自隐孢子虫的抗炎性二芳基醚
2. Inhibition of inflammatory mediators and reactive oxygen and nitrogen species by some depsidones and diaryl ether derivatives isolated from Corynespora cassiicola, an endophytic fungus of Gongronema latifolium leaves [J] . OkoyeF.B.C., NworuC.S., AkahP.A., Immunopharmacology and immunotoxicology . 2013,第1a6期

机译：弓形虫叶片内生真菌Corynespora cassiicola分离的一些十足类和二芳基醚衍生物对炎症介质和活性氧和氮的抑制作用
3. Inhibition of inflammatory mediators and reactive oxygen and nitrogen species by some depsidones and diaryl ether derivatives isolated from Corynespora cassiicola, an endophytic fungus of Gongronema latifolium leaves [J] . OkoyeF.B.C., NworuC.S., AkahP.A., Immunopharmacology and immunotoxicology . 2013,第1a6期

机译：一些Dealianodone和二芳基醚衍生物的抑制抑制炎症介质和反应性氧和氮物质从Corynespora Cassiicola中分离，戈尔科姆·荔枝叶的内生真菌
4. (00373)Cloning and sequencing of the gene encoding the enzyme for the reductive cleavage of diaryl ether bonds of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)in Geobacillus thermodenitrificans UZO 3 [C] . Suzuki Y., Nakamura M., Otsuka Y. International Conference on Environmental Science and Technology . 2019

机译：（00373）编码酶的酶法的基因的克隆和测序，用于Geobacillus Thermodentifificans Uzo 3的2,3,7,8-四氯二苯甲基-P-二恶英（TCDD）的二芳基醚键的减少切割
5. Photochemistry of chlorinated and brominated diaryl ether environmental contaminants. [D] . Rayne, Sierra. 2005

机译：氯化和溴化二芳基醚环境污染物的光化学。
6. In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors [O] . Tarek S. Ibrahim, Ehab S. Taher, Ebtihal Samir, 2020

机译：二芳基醚三氯胺类类似物的体外抗致剂活性和物理化学表征作为潜在的Inha还原酶抑制剂
7. Synthesis of Diverse oArylthio-Substituted Diaryl Ethers by Direct Oxythiolation of Arynes with Diaryl Sulfoxides Involving Migratory OArylation [O] . -1

机译：用迁移迁移亚芳基因的芳樟醇直接羟基羟基羟基醚合成各种氧化胺取代的二芳基醚

3′-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory diaryl ethers from a Steganospora species

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