Isolation and characterization of LS1924A, a new analog of emycins

ChenC.; SongF.; GuoH.; Abdel-MageedW.M.; BaiH.; DaiH.; LiuX.; WangJ.; ZhangL.

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Isolation and characterization of LS1924A, a new analog of emycins

机译：新型霉素的类似物LS1924A的分离与表征

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In the course of our screening program for new bioactive compounds from our natural product library,1 a number of 'talented' strains were discovered based on their bioactivity spectrum or novel peaks on liquid chromatography-diode array detection-mass spectrometry (LC-DAD-MS) analysis. A Streptomyces sp. LS1924 strain was found to have the ability to produce bioactive metabolites and was selected to be studied further leading to the discovery of LS1924A (1), a new analog of emycins, together with three known compounds of angucyclinone family. In this paper, we report the fermentation, isolation, chemical characterization of these compounds and the bioactivity of the new compound.

机译：在我们从天然产物库中筛选出新生物活性化合物的程序中，1根据其生物活性谱或液相色谱-二极管阵列检测质谱法（LC-DAD- MS）分析。链霉菌发现LS1924菌株具有产生生物活性代谢物的能力，并被选择进行进一步研究，从而发现了新的安霉素类似物LS1924A（1）以及三种已知的古环素酮家族化合物。在本文中，我们报告了这些化合物的发酵，分离，化学表征以及新化合物的生物活性。

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《The Journal of Antibiotics: An International Journal》 |2012年第8期|共3页
作者
ChenC.; SongF.; GuoH.; Abdel-MageedW.M.; BaiH.; DaiH.; LiuX.; WangJ.; ZhangL.;
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正文语种 eng
中图分类药学;
关键词
angucyclinone; cytotoxicity; emycins; HepG2; LS1924A; Streptomyces sp. LS1924;

机译：安古环素;细胞毒性;霉素;HepG2;LS1924A;链霉菌LS1924;

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Isolation and characterization of LS1924A, a new analog of emycins

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