WA8242A(1), A(2) and B, novel secretory phospholipase A(2) inhibitors produced by Streptomyces violaceusniger - II. Biological properties

Yoshimura S.; Muramatsu Y.; Fujiwara T.; Okamoto M.; Hashimoto S.; Okuhara M.; Otsuka T.

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WA8242A(1), A(2) and B, novel secretory phospholipase A(2) inhibitors produced by Streptomyces violaceusniger - II. Biological properties

机译：WA8242A（1），A（2）和B，由紫链霉菌产生的新型分泌型磷脂酶A（2）抑制剂-II。生物学特性

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WA8242A(1), A(2) and B, novel inhibitors of secretory phospholipase A(2) (PLA(2)), were obtained from Streptomyces violaceusniger No, 8242, WA8242B inhibited secretory group I and II PLA(2)s in a dose-dependent manner. The mode of inhibition of group II PLA(2) by WA8242B was in competitive fashion. WA8242B inhibited group II PLA(2)-induced Prostaglandin I-2 (PGI(2)) production by human umbilical vein endothelial cells. Furthermore, WA8242B was effective in mouse zymosan writhing model. [References: 13]

机译：WA8242A（1），A（2）和B（分泌性磷脂酶A（2）（PLA（2））的新型抑制剂）从Streptomyces violaceusniger No，8242获得，WA8242B抑制了I和II型PLA（2）的分泌。剂量依赖性的方式。 WA8242B抑制II组PLA（2）的模式是竞争性的。 WA8242B抑制了II组PLA（2）诱导的人脐静脉内皮细胞产生的前列腺素I-2（PGI（2））。此外，WA8242B在小鼠酵母聚糖扭曲模型中有效。 [参考：13]

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《The Journal of Antibiotics: An International Journal》 |1998年第1期|共6页
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Yoshimura S.; Muramatsu Y.; Fujiwara T.; Okamoto M.; Hashimoto S.; Okuhara M.; Otsuka T.;
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正文语种 eng
中图分类药学;药品;
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1. WA8242A(1), A(2) and B, novel secretory phospholipase A(2) inhibitors produced by Streptomyces violaceusniger - II. Biological properties [J] . Yoshimura S., Muramatsu Y., Fujiwara T., The Journal of Antibiotics: An International Journal . 1998,第1期

机译：WA8242A（1），A（2）和B，由紫链霉菌产生的新型分泌型磷脂酶A（2）抑制剂-II。生物学特性
2. WA8242A(1), A(2), and B, novel secretary phospholipase A(2) inhibitors produced by Streptomyces violaceusniger - III. Structure elucidation and total synthesis of WA8242B [J] . Yoshimura S., Takase S., Okamoto M., The Journal of Antibiotics: An International Journal . 1998,第7期

机译：WA8242A（1），A（2）和B，紫罗兰链霉菌产生的新型秘书磷脂酶A（2）抑制剂-III。 WA8242B的结构阐明和全合成
3. Fluostatins A and B, new inhibitors of dipeptidyl peptidase III, produced by Streptomyces sp. TA-3391 - I. Taxonomy of producing strain, production, isolation, physico-chemical properties and biological properties [J] . Akiyama T., Kojima F., Takahashi Y., The Journal of Antibiotics: An International Journal . 1998,第6期

机译：Fluostatins A和B是由链霉菌属（Streptomyces sp。）生产的二肽基肽酶III的新抑制剂。 TA-3391-I.生产菌株的分类，生产，分离，理化特性和生物学特性
4. DESIGN, SYNTHESIS AND BIOASSAY OF SECRETORY PHOSPHOLIPASE A2 INHIBITORS [C] . Guangyan Zhou International symposium for Chinese organic chemists . 2000

机译：分泌磷脂酶A2抑制剂的设计，合成和生物测定
5. Biological and chemical studies on the antifungal compounds produced by Streptomyces violaceusniger YCED-9. [D] . Trejo-Estrada, Sergio Ruben. 1997

机译：紫色链霉菌YCED-9产生的抗真菌化合物的生物化学研究。
6. Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation molecular cloning and biological properties. [O] . S Lizano, Y Angulo, B Lomonte, 2000

机译：来自Cerrophidion（Bothrops）godmani血浆中的两种磷脂酶A2抑制剂可从其自身毒液中选择性抑制两种不同的II型磷脂酶A2肌毒素：分离分子克隆和生物学特性。
7. WA8242A1, A2 and B, Novel Secretory Phospholipase A2 Inhibitors Produced by Streptomyces violaceusniger. II. Biological Properties. [O] . SEIJI YOSHIMURA, TAKANAO OTSUKA, YUKO MURAMATSU, 1998

机译：WA8242A1，A2和B，新型分泌磷脂酶A2抑制剂由Streptomyces violaceusniger产生。 II。生物学性质。
8. STUDIES ON THE MECHANISM OF ACTION OF THERMAL NEUTRONS IN PRODUCING BIOLOGICAL EFFECTS. II. COMPARATIVE EFFECTIVENESS IN PRODUCING INTESTINAL DAMAGE, LETHALITY, AND MARROW DAMAGE IN RATS [R] . John B. Storer, John E. Furchner 1954

机译：热中子产生生物效应的机理研究。 II。大鼠肠道损伤，致死和损伤的比较效果

WA8242A(1), A(2) and B, novel secretory phospholipase A(2) inhibitors produced by Streptomyces violaceusniger - II. Biological properties

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