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首页> 外文期刊>The Journal of Antibiotics: An International Journal >A new pseudodepsidone from the Antarctic lichen Stereocaulon alpinum and its antioxidant, antibacterial activity
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A new pseudodepsidone from the Antarctic lichen Stereocaulon alpinum and its antioxidant, antibacterial activity

机译：一种来自南极地衣性立体固形体的新假二哌酮及其抗氧化，抗菌活性

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摘要

Several species of lichens have been used for various remedies in folk medicine since ancient time and variety of biologically active lichen metabolites, including antibiotic, antimycobacterial, antiviral, analgesic, antioxidant and antipyretic properties, have been described.1 During surviving strategy against extreme environment, especially, high UV, Antarctic plants have been believed to produce unique types of metabolites.2 Several lichen species of the Antarctic origin have shown antibacterial and antioxidant activities.3"5 In our previous studies of isolation of bioactive metabolites from Antarctic lichens, lobaric acid and related metabolites showing protein tyrosine phosphatase IB inhibitory activities have been isolated from Stereocaulon alpinum of Antarctic origin.6 Moreover, antibacterial and antioxidant activity showing compounds: ramalin and three new derivatives of usnic acids were isolated from Ramalina trebrata.7's In the course of our continuing study in this area, a structurally new pseudodepsidone-type metabolite, lobastin, was encountered from the new collection batch of S. alpinum from Antarctica. This report describes the isolation, structure elucidation and comparative biological activities including antimicrobial and antioxidant activities of the lobastin encountered in this study.
机译：自古以来，数种地衣已用于民间医学的各种疗法，并描述了多种具有生物活性的地衣代谢物，包括抗生素，抗分枝杆菌，抗病毒，止痛药，抗氧化剂和退热药。1在极端环境下的生存策略中，特别是，高紫外线的南极植物被认为会产生独特类型的代谢物。2南极起源的几种地衣物种已显示出抗菌和抗氧化活性。3“ 5在我们先前从南极地衣中分离出生物活性代谢物的研究中，叶酸从南极来源的立体立体果中分离出了具有蛋白质酪氨酸磷酸酶IB抑制活性的相关代谢产物。6此外，还从化合物Ramarina trebrata中分离出了具有抗菌和抗氧化活性的化合物：ramalin和3种新的松萝酸衍生物7。在这方面继续研究结构上，从南极洲的新一批高山链球菌中发现了新的假二吡啶酮类代谢产物洛伐汀。该报告描述了该研究中所遇到的洛伐汀的分离，结构阐明和比较生物活性，包括抗微生物和抗氧化活性。

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