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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Comparison of the clinical risk factors between Candida albicans and Candida non-albicans species for bloodstream infection
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Comparison of the clinical risk factors between Candida albicans and Candida non-albicans species for bloodstream infection

机译：白色念珠菌和非白色念珠菌感染血液的临床危险因素比较

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The purpose of this study is to investigate the risk factors and susceptibilities to antifungal agents of Candida albicans and Candida non-albicans species (spp.) in candidemia cases in Kobe University Hospital. We investigated all consecutive patients with candida bloodstream infection (BSI) from 2008-2013 for whose full data were available for analyses, examining clinical factors such as gender, general complications, postoperative status or susceptibilities to antifungal agents. These factors were also compared between Candida albicans spp. and Candida non-albicans by univariate and multivariate analyses. Univariate analyses showed a significantly higher rate of Candida non-albicans species BSI patients cancer (odds ratio (OR) (95% confidence interval (CI))=2.29 (1.04-5.06) and P=0.040), chemotherapy (OR=4.35 (1.11-17.1) and P=0.035), fluconazole (FLCZ) resistance (OR=77.3 (4.51-1324) and P=0.003), and itraconazole (ITCZ) resistance (OR=15.6 (5.39-45.1) and P<0.001) and lower rate of underlying cardiovascular diseases (OR=0.27 (0.09-0.80) and P=0.018) and postoperative status (OR=0.35 (0.16-0.77) and P=0.035) in than Candida albicans. Multivariate analyses demonstrated that Candida non-albicans spp. had significantly higher rate of chemotherapy (OR=4.44 (1.04-19.0) and P=0.045), FLCZ resistance (OR=5.87 (2.01-17.1) and P=0.001), and ITCZ resistance (OR=18.7(5.77-60.4) and P<0.001) and lower rate of underlying cardiovascular diseases (OR=0.25 (0.08-0.82) and P=0.022) than Candida albicans. In conclusion, this study revealed several risk factors for BSI with Candida albicans (underlying cardiovascular diseases and postoperative status) and Candida non-albicans spp. (cancer and chemotherapy), and demonstrated that Candida non-albicans spp. were more resistant to FLCZ and ITCZ than Candida albicans.
机译：这项研究的目的是调查神户大学医院念珠菌血症病例中白色念珠菌和白色念珠菌（spp。）的抗真菌药的危险因素和敏感性。我们调查了2008年至2013年间所有念珠菌血流感染（BSI）的连续患者，其完整数据可供分析，检查了临床因素，例如性别，一般并发症，术后状况或对抗真菌药的敏感性。还比较了白色念珠菌属之间的这些因素。和白色念珠菌通过单因素和多因素分析。单因素分析显示，念珠菌非白色念珠菌属BSI患者患癌的几率显着更高（几率（OR）（95％置信区间（CI））= 2.29（1.04-5.06）和P = 0.040），化疗（OR = 4.35（ 1.11-17.1）和P = 0.035），氟康唑（FLCZ）耐药性（OR = 77.3（4.51-1324）和P = 0.003）和伊曲康唑（ITCZ）耐药性（OR = 15.6（5.39-45.1）和P <0.001）与白色念珠菌相比，其潜在的心血管疾病发生率（OR = 0.27（0.09-0.80）和P = 0.018）和术后状态（OR = 0.35（0.16-0.77）和P = 0.035）更低。多变量分析表明，念珠菌属非白色念珠菌。具有较高的化疗率（OR = 4.44（1.04-19.0）和P = 0.045），FLCZ耐药性（OR = 5.87（2.01-17.1）和P = 0.001）和ITCZ耐药性（OR = 18.7（5.77-60.4） （P <0.001）和潜在的心血管疾病发生率低于白色念珠菌（OR = 0.25（0.08-0.82）和P = 0.022）。总之，这项研究揭示了白色念珠菌和潜在的白色念珠菌与BSI的几种危险因素。 （癌症和化学疗法），并证明念珠菌属非白色念珠菌。比白色念珠菌更耐FLCZ和ITCZ。

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