Synthesis and Properties of 7-Acetyl-8-aryl-9-cyano-3-hydroxy-6-methyl-3,4-dihydro-2H,8H-pyrido[2,1-b][1,3]thiazines

A. Krauze; L. Sile; R. Danne; G. Duburs

首页> 外文期刊>Chemistry of heterocyclic compounds >Synthesis and Properties of 7-Acetyl-8-aryl-9-cyano-3-hydroxy-6-methyl-3,4-dihydro-2H,8H-pyrido[2,1-b][1,3]thiazines

【24h】

Synthesis and Properties of 7-Acetyl-8-aryl-9-cyano-3-hydroxy-6-methyl-3,4-dihydro-2H,8H-pyrido[2,1-b][1,3]thiazines

机译：7-乙酰基-8-芳基-9-氰基-3-羟基-6-甲基-3,4-二氢-2H，8H-吡啶基[2,1-b] [1,3]噻嗪的合成及性质

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

7-Acetyl-8-aryl-2-(1-chloro-2-hydroxy-3-propyl)thio-9-cyano-6-methyl-1,4-dihydropyridines were obtained by treatment of 1,4-dihydropyridine-2(3H)-thiones with epichlorohydrin in the presence of sodium bicarbonate. When treated with NaOMe, these compounds are readily intramolecularly alkylated with formation of 7-acetyl-8-aryl-3-hydroxy-9-cyano-6-methyl-3,4-dihydro-2H,8H-pyrido[2,1-b]-[1,3]thiazines. We have studied amination of 2-(1-chloro-2-hydroxy-3-propyl)thio-1,4-dihydropyridines and acylation of 3-hydroxy-3,4-dihydro-2H,8H-pyrido[2,1-b][1,3]thiazines.

机译：通过处理1，4-二氢吡啶-2，获得7-乙酰基-8-芳基-2-（1-氯-2-羟基-3-丙基）硫基-9-氰基-6-甲基-1,4-二氢吡啶。在碳酸氢钠存在下，将（3H）-硫酮与环氧氯丙烷一起使用。当用NaOMe处理时，这些化合物很容易被分子内烷基化，形成7-乙酰基-8-芳基-3-羟基-9-氰基-6-甲基-3,4-二氢-2H，8H-吡啶基[2,1- b]-[1,3]噻嗪。我们研究了2-（1-氯-2-羟基-3-丙基）硫基1,4-二氢吡啶的胺化和3-羟基-3,4-二氢-2H，8H-吡啶基[2,1-的酰化作用b] [1,3]噻嗪。

著录项

来源
《Chemistry of heterocyclic compounds》 |2005年第9期|共5页
作者
A. Krauze; L. Sile; R. Danne; G. Duburs;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类杂环化合物;
关键词
2-alkylthio-1; 4-dihydropyridines; 1; 4-dihydropyridine-2(3H)-thiones; 3; 4-dihydro-2H; 8H-pyrido2; 1-b1; 3thiazines; epichlorohydrin; amination; acylation;

机译：2-烷硫基-1;4-二氢吡啶;1;4-二氢吡啶-2（3H）-硫酮;3;4-二氢-2H;8H-吡啶[2;1-b] [1;3]噻嗪;表氯醇;胺化;酰化;

相似文献

外文文献
中文文献
专利

1. Synthesis and Properties of 7-Acetyl-8-aryl-9-cyano-3-hydroxy-6-methyl-3,4-dihydro-2H,8H-pyrido[2,1-b][1,3]thiazines [J] . A. Krauze, L. Sile, R. Danne, Chemistry of heterocyclic compounds . 2005,第9期

机译：7-乙酰基-8-芳基-9-氰基-3-羟基-6-甲基-3,4-二氢-2H，8H-吡啶基[2,1-b] [1,3]噻嗪的合成及性质
2. Synthesis of Hexahydro-thiazolo[3,2-a]pyridin-5-ones and Hexahydro pyrido[2,1-b][1,3] thiazin-6-ones Systems by Radical-Initiated Cyclization of 3-Aldenol-2-emthylene-1,3-thiazolidines and -tetrahydor-1,3-thiazines [J] . Stanislaw Lesniak, Joanna Flisinska Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2001,第1期

机译：自由基引发的3-Aldenol-2-的环化反应合成六氢噻唑并[3,2-a]吡啶-5-酮和六氢吡啶并[2,1-b] [1,3]噻嗪-6酮体系1,3-亚乙基噻唑烷和-1,3-噻嗪
3. A silver(Ⅰ)-catalyzed cascade bicyclization strategy for synthesis of 5H-benzo[d]tetrazolo[5,1-b][1,3] thiazines [J] . Miao Jiankang, Zhang Yahui, Sang Xiaoyan, Organic & biomolecular chemistry . 2019,第9期

机译：银（Ⅰ）催化的级联双环化策略合成5H-苯并[d]四唑[5,1-b] [1,3]噻嗪
4. Synthesis and Physicochemical Properties of 2,7-Dialkylated Phenanthro2,1-b:7,8-b'dithiophenes [C] . Zhenfei Ji, Hiroki Mori, Yasushi Nishihara 日本化学会春季年会講演予稿集 . 2018

机译：2,7-二烷基化菲的合成和物理化学性质2,1-B：7,8-b'二硫代
5. Part I. Synthesis of fluorinated astaxanthins. Part II. Synthesis and properties of sterically hindered 1,4-diphenyl-1,3-butadienes. [D] . Liu, Jin. 1997

机译：第一部分：氟化虾青素的合成。第二部分空间位阻的1,4-二苯基-1,3-丁二烯的合成与性能。
6. 2-[6-(4-Bromophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-N-[8-(4-hydroxyphenyl)-2-methyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl]acetamide ethanol disolvate [O] . Mehmet Akkurt, Elif Gürsoy, Nuray Ulusoy Güzeldemirci, 2015

机译：2- [6-（4-溴苯基）咪唑并[2,1-b] [1,3]噻唑-3-基] -N- [8-（4-羟基苯基）-2-甲基-3-氧代-1 -thia-4-azaspiro [4.5] decan-4-yl]乙酰胺乙醇二油酸酯
7. Regioselective synthesis of 1,3-thiazines by sequential 4-oxothiazolidine to 1,2-dithiole to 1,3-thiazine transformations: Role of intramolecular non-bonded S⋅⋅⋅O interactions [O] . Ar Rašović, A Peter J. Steel, B Erich Kleinpeterc 2016

机译：顺序选择性合成1,3-噻嗪通过顺序4-氧噻唑烷到1,2-二硫醇到1,3-噻嗪转化：分子内非键合s⋅⋅⋅O相互作用的作用

Synthesis and Properties of 7-Acetyl-8-aryl-9-cyano-3-hydroxy-6-methyl-3,4-dihydro-2H,8H-pyrido[2,1-b][1,3]thiazines

摘要

著录项

相似文献

相关主题

期刊订阅